| Ordered mesoporous carbon nanoparticles(OMCNs)have attracted considerable attention due to their geometric symmetry,good fluidity,high specific surface area,large pore volume,good biocompatibility and mechanical and thermal stability.Due to its excellent properties,ordered mesoporous carbon nanoparticles have great application value and potential in the fields of drug carrier,adsorption,electrochemistry and catalytic separation.However,due to the fact that the formation mechanism of ordered mesoporous carbons(OMCs)is still in its infancy,there are still many challenges in controlling the morphology,particle size and pore structure of OMCs.Moreover,the most commonly used methods to prepare OMCs at present,such as hard template method,solvent evaporation induced self-assembly method and hydrothermal method,have the defects of complicated synthesis process,high cost and difficult to control morphology.This greatly limits the application and scale production of OMCs.In this paper,a series of OMCNs with dispersed,uniform,adjustable morphology and particle size were synthesized by a simple and efficient synthesis method.At the same time,the formation mechanism of ordered mesoporous structure is deeply studied in order to provide theoretical basis and guidance for the further scale and customization of OMCs.On this basis,the biopharmaceutical II drug(BCSII)was selected as the model drug,and its performance as drug carrier was investigated.Finally,functional exploration was carried out to prepare magnetic OMCNs,and its adsorption performance and magnetic separation effect were investigated.This paper mainly includes the following aspects:1.Resorcinol and urotropine were selected as the carbon source,and F127 was used as the soft template.The OMCNs were synthesized under acidic conditions by a one-step aqueous solution method.Through the in-depth exploration of the formation mechanism of ordered mesostructures,the selfassembly mechanism of micelle composite units is proposed innovatively,which provides a powerful theoretical support for the development of ordered mesoporous materials.In addition,through the loading and release experiments of indomethacin,it is shown that ordered mesoporous carbon nanospheres can significantly increase the release rate of poorly soluble drugs.2.For the first time in the same system,the transition of OMCNs from rhombohedral dodecahedral to spherical shape was achieved only by changing the amount of F127.Moreover,the obtained colloidal composite particle size has a linear relationship with the amount of F127(0.30 to 0.65 g).Since the sample carbonization shrinkage is substantially uniform,the particle size of the sample is predicted by the amount of F127.The mechanism of the change in the morphology and particle size of the sample was found to be a change in the interaction force between the micelle composite units.This finding laid the foundation for the customized synthesis of OMCs.Finally,albendazole was selected as a poorly soluble drug model to compare the release properties of three ordered mesoporous carbon particles with different morphology and particle size.3.Under the premise of ensuring that the mesostructure of OMCNs is not damaged,it is magnetized to achieve rapid separation for recycling.Here,we have created a completely new method,which directly uses iron wire to dope the colloidal compound,and successfully prepares OMCNs with good magnetic separation effect.In addition,methylene blue(MB)was selected as the molecular model of the dye,and the material prepared by the method was subjected to adsorption experiments on MB. |
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