Study On The Intelligent Drug Delivery Method Of Electronic Capsule For Gastrointestinal Drug Delivery

As the pace of people's life is speeding up,their living pressure is also getting higher,irregular diet and food safety problems result in the rising of the incidence of chronic gastrointestinal disease.As the both important means of the treatment of gastrointestinal disease and the study of regional drug absorption,the gastrointestinal fixed drug delivery system has gradually become a hotspot in the international biomedical engineering field.It reaches to the lesion by the positioning system,and the drug is pushed off by the driving device.Compared with the traditional way to swallow drugs,the gastrointestinal fixed drug delivery system can be directly and efficiently administered in the inflammation,wound and lesions,not only can enhance the absorption of drugs to achieve efficient treatment,but also can reduce the side effects of drugs,accordingly performing the interventional medical treatment such as targeted administration safety and non-invasive.In addition,it also provides a reliable drug delivery method for the study of human drug absorption.To achieve fast and reliable drug delivery in the lesion,in this paper,we present an intelligent drug delivery method which can realize the intelligent control of the drug release rate,release dose and release time.First of all,we present an electromagnetic-permanent magnet driving way of drug delivery,and establish the mathematical model of the magnetic driving device,and design the structure of the driving device rationally,and get a new type of magnetic driving theory.Then we optimize the parameters of the driving device by the finite element simulation and orthogonal test theory.At last,we design an intelligent drug delivery method based on the optimized parameters of the driving device,this paper is mainly about the design of the drug delivery driving device and the intelligent drug delivery method.The design of the drug delivery driving device: firstly we calculate and analyze the magnetic field force of the electromagnetic-permanent magnet driving device,and ensure the factors that influence the drug release driving force,then make true the factor level table of the orthogonal experiment by the single factor experiment,next through the visual analysis and variance analysis of the orthogonal experiments' results,we determine the optimal structure parameters of the capsule driving device,accordingly the opening pressure of the release check valve is determined,at last,we validate the feasibility of the drug delivery device.The design of the intelligent drug delivery method: firstly we ensure the control principle by the Bernoulli equation,the principle via the intelligent control of the driving current of electromagnetic-permanent magnet driving device to control the driving force,so as to indirectly control the release dosage,release rate and release times.The driving force is also related to the attitude angle and the excitation current of the drug delivery capsule: therefore we design the method of obtaining the attitude angle of the capsule based on MPU6050 six-axis sensor combined with three sine theorem;to obtain the relationship between the drug delivery device driving force and the excitation current,first of all,we design the principle prototype of the electromagnetic-permanent magnet driving device,and set up the drug delivery driving force test platform,then through the experiment measures the driving force with the different excitation current and the release actuator stroke,finally,the function surface is fitted between the driving force and the exciting current and the actuator travel based on the least squares principle.At last,we validate the intelligent drug delivery method by the experiment,the result shows that the method is feasible and effective.