Au NR@Semiconductor Nanoparticles For Photoexcitation Enhanced Glucose Sensing And Photothermal Properties

Precious metals-metal oxides and precious metals-metal sulfide semiconductor nanocomposites have many excellent properties and can be widely used in the fields of glucose sensing,photothermal therapy,bioimaging,photocatalytic degradation of pollutants,etc.The focus of research on materials is currently focused on the regulation of the morphology of nanoparticles to show different properties.In this paper,Au NR-Cu2O and Au NR-Cu7S4 nanocomposites were studied.Based on the study of structural regulation properties,the effects of photoexcitation on glucose sensing performance were investigated by means of photoexcitation.Au-semiconductor nanocomposites with different morphological structures(hot dogs,core-shell,?,yolk-shell)were prepared,and the light of Au NR-Cu2O and Au NR-Cu7S4 nanocomposites with different morphologies was investigated.Thermal conversion performance,the main work of this paper is as follows:The Au NR was prepared by the seed method,and the liquid-reduction method was used to synthesize hot-dog Au NR@Cu2O NPs(hereinafter referred to as HD NPs)and core-shell Au NR@Cu2O NPs(hereinafter referred to as CS NPs)by controlling the ratio of Au to Cu2+.The HD/CS NPs were applied to photocatalytic glucose sensing.The results of electrochemical tests showed that the response current of HD NPs in the case of photoexcitation was 133%higher than that in the absence of light.The linear detection range of HD NPs in electrochemical glucose sensing is 0.1?5 mM,the sensitivity is 486.2?A·mM-1cm-2,the detection limit is 0.1 ?M,and it has excellent anti-interference.In addition,in the photothermal experiment,the temperature of HD NPs increased by 15.2 ? after 10 min of 0.3 W 1064 nm near-infrared laser irradiation.Using HD/CS Au NR @ Cu2O NPs as template,?-shaped Au NR @ Cu7S4 NPs(hereinafter referred to as?NPs)and yolk-shell Au NR@Cu7S4 NPs(hereinafter referred to as YS NPs)were further prepared.The results of photothermal experiments on ?NPs,YS NPs and Cu7S4 NPs showed that the temperature of 0.8 mg/mL ? NPs increased by 18.3 ? after being irradiated by laser at 0.3 W 1064 nm for 10 min,showing the best photothermal conversion performance.The results of electrochemical glucose sensing experiments on ?NPs and YS NPs showed that the detection sensitivity of ? NPs glucose was 510.2?A·mM-1cm-2,and the glucose detection limit was 0.1 ?M.Under the illumination of the white light,the glucose sensing response current at the oxidation peak potential is 85%higher than that in the absence of light.At the same time,it shows better anti-interference.Finally,rat bone marrow mesenchymal stem cells(MSC)and A549 lung cancer cells were used as experimental subjects.The cytotoxicity of ? Au NR@Cu7S4 NPs at different concentrations was studied by CCK-8 method.The results showed that when the concentration of ? NPs was below 0.1 mg/mL,it showed lower biotoxicity.In this paper,the synergy between Au-Cu2O/Cu7S4 nanocomposites was used to explore its application in glucose sensing and photothermal.The photo-excitation method enhances the performance of Au-Cu2O/Cu7S4 materials in glucose sensing,and enhances the photothermal conversion performance of such materials by constructing a novel ?-shaped structure Au-Cu7S4 NPs.The research in this paper provides new ideas and methods for designing efficient non-enzymatic glucose sensing materials and photothermal materials.