Iron-Catalyzed Intramolecular C-H Amination Of Organic Azides

This thesis deals with the iron-catalyzed intramolecular C-H amination reactions of organic azides.It is divided into three chapters.The first chapter is a literature review on the iron-catalyzed C-H amination of organic azide compounds.According to the types of azides,recent progresses in this line are introduced separately for the reactions of alkyl azides,aryl/vinyl azides and acyl/sulphonyl azides.The second and third chapters describe the research work conducted during the graduate study.It is summarized as follows:1.A simple catalytic system consisting of FeCl₂ and?-dikerimine ligands was used to catalyze the intramolecular C?sp³?-H amination of?-azidyl amides.The reactions proceeded in high efficiency,affording polysubstituted imidazolinones in good to excellent yields.The protocol provides a simple and atom-economical approach towards imidazolinones.2.The possibility of effecting azide-involved aryl C?Ar?-H amination under iron catalysis was preliminarily explored by using methyl-2-azido-3-phenylpropanoate as the model compounds.The expected result was not obtained despite extensive screening of catalytic conditions.Instead,methyl-2-amino-3-phenylacrylate was generated from methyl-2-azido-3-phenylpropanoate as a result of denitrogenation and hydrogen migration.