Studies On The Ring-opening Reaction Of Three Membered Ring Compounds Via Visible Light Photocatalysis

Visible light is abundant in nature,and has the characteristics of green,nontoxic,waste-free and pollution-free which can be used as a sort of renewable source.Using of visible light photocatalysis in organic synthesis is not only in accordance with the concept of green chemistry,but also could obtain the products which are difficult to get by the traditional catalysis method.The three membered ring is the smallest cyclic compound with high ring tension and reactivity.If the ring-opening reaction of the three membered ring is catalyzed by the eco-friendly visible light photocatalytic system rather than traditional organic reagent?transition metal,lewis acid or base?,it is of great significance and has important application in the fields of medicine synthesis and the research of biological activity.Therefore,the ring-opening reaction of aziridines and cyclopropenyl dicarboxylates is mainly studied via visible light photocatalysis in this thesis.This paper is divided into three parts:The first chapter is literature review.Few researches on the ring-opening reaction of aziridines and cyclopropenyl dicarboxylate compounds are reported under the conditions of visible light photocatalysis.The research progress of amines and olefins reactions will be mainly introduced via visible light photocatalysis in this chapter.The second chapter elaborate that the photocatalyst Ru?bpy?₃?BF₄?₂ can successfully catalyze the synthesis of substituted 2-imine-thiazolidine derivatives by[3+2]cycloaddition of aziridines with isothiocyanates via visible light photocatalysis using PhN₂BF₄ as an oxidant.Thiazoline compounds can not only serve as the core structures in some biological and medical active compounds but also have important applications in drug synthesis.The third chapter is that the regioselective oxidative ring-opening reaction of cyclopropenyldicarboxylatederivativesefficientlygeneratedsubstitued acylmethylidenemalonatescompoundsundertheconditionof Ir[dF?CF₃?ppy]₂?dtbbpy?PF₆ as the photocatalyst and 7W blue LED lamp.The reaction is mild and insensitive to H₂O and O₂.Synthesis of the raw materials is simple and easy,and the yield of products is moderate.Acylmethylidene malonate compounds are very important drug intermediates and have practical application value in drug synthesis and natural product.