Magnetic Chitosan Composite Microspheres:Synthesis And Adsorption Property For Ibuprofen

Magnetic chitosan microspheres have been widely used in sewage treatment due to non-toxicity,biocompatibility,regeneration,low cost and magnetic response.In this paper,the preparation of magnetic chitosan microspheres?Fe₃O₄@CS?was optimized based on the particle size and distribution,and then toxic effects of Fe₃O₄@CS on zebrafish embryos were studied.Magnetic chitosan composite microspheres were prepared with polyethylenimine?PEI?,the effects of PEI on the microsphere structure and adsorption capacity were analyzed.A brief summary of results is as follow:?1?Glutaraldehyde as crosslinking agent,the preparation of Fe₃O₄@CS was in emulsion system,The effects of different experimental conditions on the particle size and distribution of Fe₃O₄@CS were studied,the adsorption of ibuprofen on Fe₃O₄@CS obtained from the Langmuir model was 61.54 mg/g.?2?Using different particle size of Fe₃O₄@CS to prepare different concentration solution,which exposed on zabrafish embryos.We found that hatching rate and mortality of zebrafish embryos in experimental group and the negative control group were similar,indicating that in this size and concentration range of Fe₃O₄@CS has no obvious toxicity on zebrafish embryos.?3?Fe₃O₄@CS were modified by PEI,found that with the increase of PEI,the particle size of microspheres showed a decreasing trend,and the adsorption capacity of ibuprofen increased;The adsorption of ibuprofen on Fe₃O₄@CS/PEI conform to Langmuir adsorption isotherm and the second-order kinetic model.The maximum adsorption capacity of ibuprofen on Fe₃O₄@CS/PEI obtained from the Langmuir model was 138.63mg/g,more than double that of the microsphere without PEI,with good reusability.