Optimization Of Prescription Technology Of Edible Film Material Of Plant And Its Application In Pharmaceutical Process

At present,gelatin is the main component of soft capsule shell.With the increase of medical varieties and technological progress,the disadvantages of gelatin capsule have gradually appeared.In this study,corn modified starch,carrageenan,pectin and chitosan were used as materials to prepare edible plant film,and their properties were detected,to provide a theoretical basis for plant soft capsules to better substitute gelatin soft capsules.The preparation of pH-sensitive microcapsules with chitosan and alginate as raw materials provides a basis and reference for the development of targeted preparations.The main research contents are as follows: 1.Preparation technology of plant soft capsule shellBy using carrageenan and modified starch as main materials,the capsule shell of plant soft capsule was prepared by changing the quality of each factor with D-optimal mixture design.The capsule shell was performed analysis of mechanical properties and water vapor permeability coefficience using response surface methodology,and the optimum formulation of capsule shell was optimized.The results showed that when glycerol and water were maintained in a certain amount,the tensile strength of capsule shell reached the maximum,Young's modulus and water vapor permeability were the minimum,and the performance of capsule shell was the optimal,with 0.9g K-carrageenan,10.5g L-carrageenan,oxidized starch 1.636 g and 16.964 g heat treated starch.2.Preparation technology of pH-sensitive plant edible filmThe effects of mass fractions of oxidized starch,pectin and glycerol on the tensile properties of pH-sensitive film were studied by response surface methodology.On the basis of single factor experiment,a quadratic regression equation was established with the mass fraction of oxidized starch,pectin and glycerol as the influencing factors and the tensile strength of the composite membrane as the response value by using center combination test.The optimal combination was obtained by response surface analysis,and then the dissolution rate of the membrane was determined by simulating the pH environment of human gastrointestinal tract.The results showed that when the mass fractions of oxidized starch,pectin and glycerol were 3.97%,2.50% and 10.00%,respectively,the tensile strength of the film reached the maximum.In the simulated gastric juice environment,the film was almost insoluble,while in the simulated intestinal juice environment,the dissolution rate was 83%,which showed that the film had obvious pH sensitivity.3.Preparation and properties of edible pomegranate peel antimicrobial filmThe effect of the amount of pomegranate peel on the film-forming properties of starch composite films was studied,and the microstructure and properties of the films were observed.The results showed that with the increase of pomegranate peel content,the breaking elongation,light transmittance and water solubility of starch antimicrobial film decreased,while the tensile strength,thickness and antimicrobial activity increased.The results showed that pomegranate peel could inhibit the growth of Staphylococcus aureus and Escherichia coli.4.Preparation and sustained-release properties of pH-sensitive microcapsulesSodium copper chlorophyll microcapsules were prepared by using chitosan-alginate microcapsules.The encapsulation efficiency was taken as the optimization index of preparation process.The optimal scheme was obtained by orthogonal experiment.The controlled release effect of microcapsules in simulated gastric juice and intestinal juice was investigated.The results showed that the optimum preparation scheme of the microcapsule was chitosan concentration of 3 mg/mL,alginate concentration of 30 mg/mL and calcium chloride concentration of 20 mg/mL.The microcapsule had good sustained release performance in simulated gastric juice and simulated intestinal juice.