Three Kinds Of Macrocyclic Supramolecular Assemblies With Hydrophobic Cavities And Biological Applications

Construction of functional supramolecular assemblies based on the noncovalent bonding interactions between host and guest molecules is still a challenge of supramolecular chemistry.Taking advantage of the dynamic reversibilities of the supramolecular assemblies,the morphologies and functions of them can be regulated expediently by the eternal stimuli.Herein,we have designed and constructed a series of functional supramolecular assemblies sustain by the host-guest interactions between functional guest molecules and three macrocycles: cucurbituril,C-Methylcalix[4]resorcinarene(MC4RA),cyclodextrin.Furthermore,the biological applications of them have be detailly investigated.The specific contents are as follows:1.The brief overview of supramolecular chemistry was introduced.Some representative progress on cucurbiturils and cyclodextrins as well as macrocyclic covalent crosslinked membrane materials were reviewed.2.A benzylimidazolium-pendent antimitotic peptide was designed and synthesized,which could specially recognize the tubulin in microtubules(MTs)and form a stable host-guest complex with cucurbit[8]uril.The intertubular aggregation of MTs could be efficiently regulated by the orthopic polypeptide-tubulin interaction and host-guest interaction,which could further trigger cell apoptosis and tumor ablation in vivo.3.Macrocyclic nano-crosslinked polymer films(p TC-MC4RA)with ultra-thin,dense and non-interstitial structure were prepared by interfacial polymerization between MC4 RA and TC.The films not only have high permeability to different solvents,but also can selectively separate organic cationic dyes.In addition,we prepared p TC-HPC-MC4 R films through doping strategy,which has the similar structure as p TC-MC4 RA films and can filter and degrade Escherichia coli in drinking water in situ.This is important for removing and killing bacteria in drinking water.4.A polysaccharide supramolecular nanoparticles were constructed from the 2-nitrobenzyl ester-modified β-cyclodextrin and adamantane-grafted hyaluronic acid via the non-covalent bonding interactions,which can be disassembled upon irradiated with UV light.Significantly,this photocontrolled topological morphology transformation can be further used in targeting anticancer drug transportation and release.