Construction Of C-P And C-N Bonds Via Radical Paths With Transition Metal Catalyst

C-H bond is the most common bond in the organic chemistry,however,it is hard to be transformed due to its' high bond energy.Since organic chemistry has been developed for several decades,how to efficiently activate C-H bond and transform it to C-N,C-O,C-S,C-X bond has been a difficulty in the field of organic chemistry.With the development of organic strategies,transition-metal catalyzed C-H bond activation to achieve functional groups and transformation through highly reactive free radicals have gradually become effective strategies to overcome this problemSynthesis of organic compounds containing phosphrous has always been a topic of interest to organic chemistry because of its unique biological activity,which has been widely used in the fields of medicine,bioactive molecules and materials.At the same time,nitrogen heterocyclic compound such as,indoles,indole ketone,carbazole,pyrrolidine,quinoline ketone and ?-lactam are an important frame in many natural products and antibiotics,so how to directly transform C-H bond to C-P bone and C-N bond has been a crucial topic,it will greatly promote the synthesis of biological drug and natural products.Taking this as the strating point,this paper explored the direct C-P bond and C-N bond transformation of C-H bond through transition-metal catslystThesis mainly includes the following three aspectsFirstly,it is mainly about the construction of C-P bond catalyzed by transition metal in recent years,including the transformation of C-X bond and C-H bond.The construction of C-N bond and the synthesis of ?-lactam are described.The research obJective and direction of the paper was describedSecondly,direct ortho phosphine acylation of 3-methylene-l-indoles-1-kotone was studied by using palladium and silver as co-catalysts.Thirdly,systhesis of ?-lactam with butylamide as substrate catalyzed by copper salt and DTBP as oxidant was studied.