Study On Copper-catalyzed Disulfonation Of Terminal Alkynes And Its [1+1+1] Cyclization Reaction

Alkynes are one of the most important chemical skeletons.The structure contains carbon-carbon triple bond functional groups and has good reactivity.They have special structures and properties and are widely used.Used in medicinal chemistry,organic chemistry,biochemistry,etc.By constructing new chemical bonds,alkynes can be converted into biologically active substances,which is also extremely important in the synthesis of drug molecules.A series of important organic molecules can be prepared based on the bis-sulfonation of alkynes and the reaction of their hydrogen azide products,but this research has not been sufficient so far,and further research is needed.The specific research in this paper is as follows:(1)Copper-catalyzed disulfonation of alkynesUnder the catalysis of monovalent copper,a one-pot simple and efficient synthesis of various functionally substituted 1,2-bissulfonyl vinyl compounds,This reaction has the advantages of simple operation,no strong oxidant,no inert atmosphere,no toxic by-products,etc.This strategy provides a new method and new strategy for the synthesis of vinyl sulfone.(2)Copper-catalyzed [1+1+1] cyclization of alkyne hydrogen azide product Based on the high reactivity of hydrogen azide products with alkynes,the [1+1+1]cyclization reaction of alkyne hydrogen azide products with chloroform under the catalysis of divalent copper was developed to achieve alkenyl.The conversion of nitrogen to cyclopropane derivatives has developed a new cyclization mode ofalkenyl azide ?-carbon and a new simple and efficient method for synthesizing cyclopropane derivatives.