The Preparation Of Hydroxyapatite Composite Material And Its Applications On Biology And Adsorption

Hydroxyapatite(HA)is an inorganic material with high biological activity and biocompatibility.In addition,due to its high specific surface area and excellent charging characteristics in water,it has a good adsorption of inorganic ions ability.Therefore,it has good application prospects in the field of biological materials and water treatment.At present,titanium alloy is an important implant in clinical medicine.However,it has some defects,such as biological inertness,stress shielding effect and easy corrosion.Therefore,it is effective to prepare a bioactive coating on its surface Means to avoid its drawbacks.Therefore,a functional bio-inorganic material is a worthy research direction.The main contents and conclusions of this paper are as follows:(1)Preparation and properties characterization of hydroxyapatite coating.HA coating was synthesized on the surface of titanium alloy by hydrothermal method.The effect of HA coating on properties of titanium alloy materials was studied,in addition,in vitro and in vivo performance of the material were studied.Research shows that coating titanium alloy material with large corrosion resistance compared with pure titanium alloy.By using the adsorption property of the HA,it was confirmed that the coated can carry levofloxacin to achieve good bacteriostatic effect,it can avoid the possibility of infection in the vicinity of the implant,thus speeding up the healing effect.In vivo experiments at the femur of rabbits showed that HA coating had a better ability to promote bone regeneration than uncoated materials.(2)Synthesis and characterization of high bioactive Fe3+doped hydroxyapatite.A series of Fe3+doping HA with different doping content has been synthesized by hydrothermal method to study the influence of Fe3+content on HA biocompatibility and morphology.And through some commonly used physical characterization to verify the structure and crystal phase of the synthetic material.The results show that Fe3+content has a certain effect on the rod-like structure of HA,the selected concentration range,doping Fe3+concentration is higher,the longer the size of the HA,also explain the possible cause of the hydrothermal method to get the rod-like structure of HA.And in vitro experiments were conducted on the synthesized doping HA and pure HA,and the biocompatibility of the materials were verified by CCK8 and Live/Dead staining.The result shows,the higher the concentration of doped Fe3+,the better the biocompatibility of HA,providing in vitro data for its application in the field of biomaterials.(3)Adsorption F-in water by Fe3+ doped hydroxyapatite.All kinds of hazardous substance discharged into the underground water layer cause extremely serious pollution to the water body.There are a large number of micro-pollutants in water pollution that are difficult to decompose,F-is one of them.The presence of high F-content in water has seriously affected people's daily drinking safety.Therefore,we selected Fe-HA synthesized in the previous chapter as the adsorbent for treating water pollution.The adsorption effect of Fe-HA on F-in water was investigated.The results confirm that Fe-HA as an adsorbent can efficiently remove F-in water,and the adsorption is mainly single adsorption,of which chemical adsorption is the main part.High temperature has a promoting effect on adsorption removal,and Fe-HA shows better performance in low pH,the scope of its better application fields is defined.