Decarboxylative Coupling Reaction Of Heterocyclic Compound And Potassium Aryldifluoroacetate

Fluorine-containing organic compounds have become more and more widely used in drug research and development,agrochemicals and materials.The fluorine-containing groups brought with F,CF₂Y?Y is an alkyl group,aromatic group,ester group,sulfonyl group,etc.?,CF₃ and others not only improve the physical and biological properties of the compound,but also strengthen its functionality.Therefore,many synthetic chemists have developed different synthetic methods,and then researchers keep applying new fluorinated molecules to the study of biological activities and compounds.This article uses the heterocyclic compounds quinoxaline-2?1H?-one,quinoline-N-oxide as reactants,which are reacted with2,2-difluoro-2-arylacetic acid potassium to study based on the above research background,details are as follows:1.It was efficiently developed that strategy for the preparation of C3-difluoroarylmethylated quinoxalin-2?1H?-one via a visible-light-induced decarboxylative C3-difluoroarylmethylation of quinoxalin-2?1H?-one with potassium2,2-difluoro-2-arylacetate in water at room temperature.This photoinduced reaction generated the desired products in good yields under simple and mild conditions2.Highly selective remote difluoroarylmethylation of quinoxalin-2?1H?-one with potassium 2,2-difluoro-2-arylacetate obtain the difluoromethylated derivative at the C2-position of oxidized quinoline.This strategywas use persulfate as oxidant,showed broad substrate scope,in good yields,without metal.