| The purpose of this article was to prepare a transdermal drug delivery patch with controlled and efficient drug release and investigate its drug release properties.Using polycaprolactone(PCL)as a drug carrier material,a transdermal drug delivery patch with graphene-like interlaced network structure(GLINS)was prepared by fused deposition modeling(FDM)printing technology.By introducing chitosan(CS)and adjusting its loading,controllable porous structures were formed on the patch as a drug release channel,which improved the problem of dense structure and achieves controlled and efficient drug release.Ibuprofen(IBP)was used as a model drug,CS/IBP/PCL filaments were prepared,and its FDM printing process parameters were optimized.On this basis,a graphene-like interlaced network structure(GLINS)transdermal drug delivery patch was designed and prepared.The effect of different formulation on processing technology,composite material properties and drug release properties were also studied.The tensile strength of the fused deposition modeling mechanical specimen and the weight of the graphene-like interlaced network structure were used to evaluate the printing result.And the effect of process parameters on the printability of CS/IBP/PCL composite was studied.All selected printing temperature,platform temperature,printing speed,layer height and nozzle diameter in this experiment can achieve the print of fused deposition modeling mechanical specimen and GLINS patch.When the printing temperature was 120?,the platform temperature was 0?,the printing speed was 60 mm/s,the layer height was 2 mm,and the nozzle diameter was 0.2 mm,the tensile strength of the fused deposition modeling mechanical specimen was the largest.And at the same time,the weight of GLINS patch was also the largest.At this time,it was the ideal fused deposition modeling process parameter.The preparation of CS/IBP/PCL 3D printing filaments with different drug content and the preparation of GLINS patch by FDM method were conducted to investigate the influence of drug content on properties of CS/IBP/PCL 3D printing filaments and drug release properties of GLINS patches.The results showed that the tensile strength,complex viscosity and storage modulus of 3D printing filaments all decreased with the increasement of drug content.GLINS patch was evaluated by scanning electron microscopy(SEM)and X-ray diffraction(XRD).IBP was dispersed in amorphous state in the matrix,and no agglomeration was observed when the drug content was 0-20 wt%.With the drug content increased,the release rate of 3D printed GLINS patches has significantly improved,from 27.9%to 99.6%.The preparation of CS/IBP/PCL composite 3D printing filaments with different CS content and the preparation of GLINS by FDM method were conducted to investigate the influence of chitosan content on properties of CS/IBP/PCL 3D printing filaments and drug release channel and drug release properties of GLINS patches.The optimal formula was:the content of polycaprolactone was 68 wt%,the content of IBP was 12 wt%,and the content of chitosan was 20 wt%.It was observed by scanning electron microscope that the most drug release channel was formed at this time,and the graphene-like interlaced network structure patches had an optimal drug release behavior.The drug release rate increased from 62.3%when CS was not added to 99.3%within 120 h.The drug release mechanism was a diffusion-erosion mechanism.Using ethyl cellulose(EC),microcrystalline cellulose(MCC)and hydroxypropyl methyl cellulose(HPMC)as release modifiers,the effects of three release modifiers on IBP/PCL 3D printing filaments properties and the drug release property of GLINS patches were studied.The mechanical properties and complex viscosity of the 3D printing filaments with MCC were the maximum,none of the three release modifiers reacted with carrier and drug and the three release modifiers were all in the amorphous state in the carrier.In addition,the release rate of the MCC release modifier on the 3D printed GLINS was the most significant. |
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