Research On Potential Regulating Optical Sensor And Drug Delivery

Metal nanoparticles are widely used in the field of biochemical sensing due to their unique optical and electrical properties.Among them,the performance of localized surface plasmon resonance(LSPR)sensors based on metal nanoparticles can be further improved through the accession of electrochemistry.Moreover,drug delivery after detecting is of great significance for the remission or cure of the disease.So first,linear scanning voltammetry coupled LSPR system based on gold-silver nanoparticle-modified nanocone arrays was used to detect sialic acid,a marker of inflammation.The specific recognition of sialic acid was achieved by modifying 4-mercaptophenylboronic acid on the surface of arrays.The results showed that the system is highly sensitive and stable.Secondly,the mechanism of potential regulating LSPR is further studied.Electrochemical deposition method was used to deposit gold nanoparticles on the surface of indium tin oxide electrode to build electrochemistry coupled optics component,and then the phenomenon of potential regulating LSPR was analyzed from the experiment and theoretical aspects.The feasibility of potential regulating LSPR was preliminarily verified,so as to lay the foundation for the transition from wavelength-scanning sensor to miniaturized potential-scanning LSPR sensor.Finally,a flexible,electronically controlled drug delivery system based on near field communication was developed to release the non-steroidal anti-inflammatory drug sodium salicylate,so as to achieve the treatment of inflammation.The NFC-enabled smartphone was used to power the system and realize data transmission.The effect of drug treatment was evaluated by temperature changes,and so a closed-loop treatment system was constructed.Among them,a constant-current electro-polymerization method was used to construct the drug delivery electrode based on bilayer polypyrrole,which can inhibition the spontaneous release of drugs.At the same time,gold nanoparticles were deposited electrochemically to improve the adhesion of electro-polymerization.The results showed that the gold nanoparticles-deposited bilayer polypyrrole electrode has significant advantages in stability and inhibiting the spontaneous release.The drug delivery system can control the release dose of drug by adjusting voltage stimuli and time to achieve on-demand administration,thus showing the great potential of system in wearable treatment of diseases.