Nickel-catalyzed Sulfonamidation Of Aryl Halides With Second Hydroxylamines

Organic compounds with sulfonamide motif widely exisit in many bioactive natural products,pharmaceutical agents and agrochemical molecules.Sulfonamides have a variety of pharmacological effects such as antibacterial,anti-carbonic anhydrase,diuretic,hypoglycemic,and anti-thyroid.The development of simple,versatile,and environmentally friendly processes or methodologies for widely used organic compounds from readily available reagents is one of the major challenges for chemists in organic synthesis.Compared to other transition metal-catalyzed methods for the synthesis of N-arylsulfonamides,the research on Ni-catalyzed methods remains largely unexplored.This dissertation focuses on the cross-coupling reaction of nickelcatalyzed Aryl halides and secondary hydroxylamine derivatives,and aims to find a new avenue to the systhesis of N-arylsulfonamides.This dissertation mainly includes the following parts:Chapter one mainly introduces the research progress of the synthesis of sulfonamides.including: traditional methods of synthesizing sulfonamides,the transition metal-catalyzed sulfonamide synthesis methods,and the transition metalcatalyzed C-H bond activation to construct N-arylsulfonamides.Based on the previous research work,we explored our design to construct N-arylsulfonamides.Chapter two and three mainly introduce our strategy :using nickel-catalyzed cross-coupling reaction of aryl halides and secondary hydroxylamine derivatives to constuct.N-arylsulfonamides.including :optimization of reaction conditons,investigation of substrate,Study and explanation of reaction mechanism.