The Electrochemical Sensor Based On Composite Of Carbon Nanomaterial And Transition Metal Material And Its Application

There are many kinds of functional molecules in the organisms.These molecules are closely related to the life activities of living organisms.It may lead to disease if the content is abnormal.For example: abnormal blood glucose is the main basis for the diagnosis of diabetes;the abnormal dopamine content is closely related to Parkinson's disease.Therefore,it is crucial to develop a simple,sensitive and reliable analysis method for the detection of these functional molecules,which is of great scientific significance and practical value for clinical diagnosis and treatment.The electrochemical detection method is one of the most important analytical methods in analytical chemistry.Due to its advantages of simple operation,low cost,fast detection speed,high sensitivity and simple modification,it has attracted extensive attention.In the field of electrochemical sensor,the interface of electrode surface determines the analytical performance.Therefore,in order to further improve the analytical performance of electrochemical sensor,it is significant to explore new electrode material.Carbon-based nanomaterial is very suitable for becoming one of the candidates because of its high specific surface area,high conductivity,and excellent catalytic performance.Besides,transition metal materials have attracted much attention because of their low cost and high electrocatalytic activity.The synergistic effect of their composites may effectively improve the detection sensitivity,selectivity,and stability of electrochemical sensors.Therefore,in this work,on the premise of exploring new electrode materials,we aimed to build non-enzymatic electrochemical sensors which based on carbon nanomaterials and trasnsition metal materials,and hoped the synergistic effect of the composites would further improve the sensitivity,selectivity and stability for glucose and dopamine detection.The detailed contents of this paper were as follows:1.Copper based metal organic framework(Cu-MOF)with octahedral morphology was synthesized by solvothermal method,and was combined with carbon nanohorns(CNHs)to construct a composite of Cu-MOF/CNHs,in which Cu-MOF served as a high efficiency electrocatalyst for the electrochemical oxidation of glucose and CNHs can significantly accelerate electron transfer of electrode surface and improve electrochemical surface area.The synergistic effect of Cu-MOF/CNHs may significantly improve the electrochemical performance of glucose analysis.The prepared Cu-MOF/CNHs/GCE owned excellent electrochemical properties,under optimized conditions,it exhibited superior electrochemical performance toward glucose in the wide range of 250 n M to 1.2 m M with a low detection limit of 78 n M(S/N=3).Meanwhile,the prepared sensor with good selectivity,reproducibility and stability has been successfully applied to real sample analysis.Notably,the detection results of glucose in human serum measured by our electrochemical sensors(5.62 m M,3.90 m M and 5.01 m M)were compared with clinical standard methods(hexokinase method),and the results were basically consistent with the clinical results(5.59 m M,3.92 m M and 5.14 m M).2.CoOOH with hexagonal morphology was simply and rapidly synthesized at room temperature,and was compounded with carbon black(CB)construct a composite of Co OOH/CB.Among them,CB as highly conductive materials can significantly accelerate electron transfer of electrode surface and improve electrochemical surface area.After being combined with Co OOH,the synergistic effect of Co OOH/CB guaranteed that trace amounts of dopamine can produce amplified output signals on the electrode surface.The constructed Co OOH/CB/GCE exhibited good electrocatalytic activity for dopamine,the redox peak potential difference decreased,and the current response value increased significantly.Under optimized conditions,it exhibited superior electrochemical performance toward dopamine in the wide range of 2 ?M to 200 ?M with a low detection limit of 0.07 ?M(S/N=3).Besides,the prepared sensor owned favorable selectivity,reproducibility and stability.