Modeling And Optimization Of Simulated Moving Bed Process For The Separation Of Glucose And Fructose

Sugars are a very important class of organic compounds,widely existing in the biological world.Various monosaccharides,oligosaccharides,and polysaccharides are a type of target product with high demand,especially in modern pharmaceutical synthesis,biopharmaceuticals,food engineering,fermentation,fine chemicals,etc.The purity of various monomer compounds directly affects The quality of these products.Simulated moving bed chromatographic separation technology is a modern separation technology proposed by UOP in the 1960 s.It uses a multi-column countercurrent operation mode to overcome the limitations of single column batch preparative chromatography,which requires high solvent consumption and relatively limited productivity.It is one of the most suitable chromatography technology for continuous large-scale industrial production.The four-zone simulated moving bed technology based on macroporous adsorption resin separation is currently the mainstream process for fructose purification.The traditional SMB with four-zone synchronous switching cannot meet all the requirements mentioned above.In addition,the separation process is a nonlinear system engineering with strong coupling of operation variables and complicated process mechanism.It studies the modeling,simulation and optimization of the simulation of the separation process of the moving bed,and designs and operates the product separation and purification process to improve the simulation of the moving bed.The economic benefits of the separation process have important guiding significance.Based on the separation of fructose and glucose as the standard system,based on the simulation of the moving bed separation process mechanism model,using the linear function as the basis function and the Jacobi orthogonal polynomialconfiguration of the finite element method,the operation optimization of the simulated moving bed separation process was compared In the end,a model study on the sequential simulation of the moving bed separation process was carried out.The main work of the thesis includes:(1)Introduce the working principle,development and application of the simulation moving bed.From the aspects of modeling and optimization of simulated moving bed,the current research directions and methods of simulated moving bed are summarized,and the main research work and article structure of this article are summarized.(2)The experiment determines the parameters of the chromatographic model,including system dead volume,detection concentration interval,filler porosity,effective mass transfer coefficient,axis diffusion coefficient,and fructose-glucose adsorption isotherm.(3)The simulated moving bed is simulated by the finite element method,the finite element method composed of different basis functions is compared,and the genetic algorithm is used to optimize the simulation results,which are combined with the experimental results,compared with the simple parameters optimized by experiment.Effective and cost-saving.The results show that the self-constructed intermittent simulated moving bed mathematical model is in line with the actual measurement data.It is suitable for the optimization of the separation process of glucose and fructose,and has important guiding significance for the optimization of the two-component separation process.