Reactive Site Regulation Fabrication,Catalytic And Photothermal Of AuNR@Cu_2-xS Supraparticles

We present a“reactive sites regulation”strategy for fabricating two kinds of AuNR@Cu_2-xS nano superstructures（SPs）with adjustable size and controllable morphology.The AuNR@Cu_2-xS SPs are biocompatible and have low nonspecific interactions,which possess preferable photothermal conversion effciency and photostability,as well as temperature dependent chemical dynamic therapy（CDT）performances.Obviously,the AuNR@Cu_2-xS SPs possess the synergistic effects of photothermal therapy（PTT）and CDT,which is potential for enhancing tumor cell killng and corresponding therapy.In detail,the dissertation includes the following four parts.In the first chapter,we summarized the discovery and development of plasmonic nanostructures firstly.Then,we presented the properties,fabrication methods and applications of plasmonic nanostructures.At last,the existing problems and our working goal were put forward,respectively.In the second chapter,through the of the reactive sites regulation strategy,in the presence of pre-synthesized AuNRs,the combination of introduced cetyl trimethyl ammonium bromide and bovine serum albumin molecules can well modulate the numbers of reactive sites on AuNRs’surface,and then regulate the topological structures of the nanohybrid to prepare two kinds of Au-Cu_2-xS SPs,namely core@shell and Janus SPs.In the third chapter,the optical properties of the crystal were calculated by finite-different time-domain（FDTD）,and it was found that the coupling effect of Au-Cu_2-xS redistributed the electric field of the crystal and enhanced the extinction of the near-infrared region.In addition to good biocompatibility and low non-specific interaction,the hybrid SPs also had enhanced photothermal conversion efficiency/photostability and temperature dependent CDT effect,which had a good killing effect on tumor cells.The fourth chapter presented the highlight of this work and potential prospects.