| The Cucurbit[n]uril?Q[n]?is a class of macrocyclic host compounds in supramolecular chemistry.It has a rigid hydrophobic cavity and two identical strong polar ports with carbonyl oxygen.It is a new type of host compound developed after cyclodextrin,crown ether and calixarene.Cucurbit[n]uril has aroused widespread attention from many researchers in the research of macrocyclic molecules,and it has become an important research direction of supramolecular chemistry.The research on the host-guest interaction and coordination chemistry based on Cucurbit[n]uril has a wide range of applications,including materials,biomedicine and environmental science.The long-standing problem of Cucurbit[n]uril chemistry is its poor solubility in water and its chemical inertness is not easy to be modified.In this paper,the common Cucurbit[7]uril?Q[7]?were derived and the fluorescent-labeled Cucurbit[n]uril with fluorescence characteristics were synthesized by clicking the reaction.?1?synthesis a fluorescent Cucurbit[n]uril with anthracene as a fluorescent group Mmol as a probe 1;?2?Synthesize a cross-shaped structure with anthracene as the fluorescent group,a fluorescently labeled citrulline Q[7]2-anthracene substituted with a double Cucurbit[n]uril at the 9,10-position as probe 2;?3?A fluorescent-labeled cucurbit Q[7]-Pyrene containing a fluorescent group was synthesized as probe 3.;?4?Synthesize a naphthalene fluorescently labeled cucurbit Q[7]-Naphthalene as probe 4.The interaction between the host and guest of probe 2 and octreopeptide acetate?Oct?was studied by ultraviolet,fluorescence,Nuclear magnetic resonance,and isothermal titration heat.The interaction between the host and guest of a Pyrene probe3 and a purple guest molecule(MV2+,EV2+)was studied.The synthetic probe 1 was used to study its application in vesicle preparation.The synthetic fluorescent-labeled melon ring can stain the cells.The cytotoxicity test was carried out,and it was proved that the three derivatives had good biocompatibility. |
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