Palladium-Catalyzed Asymmetric 1,4-Addition Of Diarylphosphines To Unsaturated Naphthoquinone Monoketal

This dissertation consists of four parts.In the first part,we mainly reviewed the development and the application of chiral phosphine ligands.In the second part,palladium-catalyzed asymmetric 1,4-addition of unsaturated ketones was described.In the third part,the design of chiral phosphine ligands was introduced.The experimental section is the last part.The synthesis of chiral phosphine ligands has been an important area due to the widespread use of chiral phosphine in asymmetric reactions.A large number of mono-,bi-,multidentate phosphine ligands have been applied to asymmetric catalytic reactions successfully.In this dissertation,we mainly focus on synthesizing chiral phosphorus compounds by palladium-catalyzed asymmetric 1,4-addition of unsaturated ketones.After further optimization,we obtained chiral phosphorus compounds in high yields(up to 96% yield)and with excellent enantioselectivity(up to 93% ee)in presence of 2.5 mol% Chiral Pincer-Pd and with toluene as solvent at-30 ?.