Study On The Synthesis Of Furanic Pharmaceutical Intermediates

With the continuous consumption of petrochemical resources,the development of greener renewable resources and the development of sustainable technologies has become an inevitable trend.As the only natural,renewable,and readily available carbon resource,biomass resources can be catalyzed into liquid fuel and high value-added chemicals,which can help solve the problem of consumption of fossil resources and environmental pollution.Furfural and 5-hydroxymethylfurfural(HMF)are essential biomass-derived furanic platform molecules,which can be used to prepare pharmaceutical intermediates and new fuel precursors through a variety of transformation pathways.Long straight chain aromatic compounds are widely used in the production of drugs and polymers with superior application value.As a class of aromatic oxygen heterocyclic compounds,biomassderived furanic compounds have vital applications in drug synthesis.At the same time,furanic compounds are naturally biodegradable,and their structure combines the flexibility of aliphatic compounds and the rigidity of aromatic compounds.Therefore,based on furfural and HMF and other important bio-based platform molecules,we developed a general synthetic method for the preparation of a variety of long straight chain furanic compounds.By preparing an efficient sodiumdoped porous manganese oxide(Na-Mn Ox)catalyst,a series of long chain furanic aldehydes were prepared by oxidative cracking reaction from furanic 1,2-diol compounds.(E)-5-(furan-2-yl)pent-4-ene-2,3-diol(FPED)was obtained from the aldol condensation reaction of biomass platform molecules furfural and 2,3-butanedione,and was used as a model substrate.Specific reaction conditions were screened for the oxidative cracking reaction,including the types and amount of catalyst,reaction temperature,reaction time,reaction solvent,additives,and the composition of the catalyst.The results showed that using Na-Mn Ox catalyst and 1-butanol as the solvent.The aerobic reaction was performed at 90 o C for 5 h,the yield of 2-furan acrolein was 91%.Besides,we further obtained the corresponding furanic carboxylic acid and alcohol compounds from the aldehyde products,which greatly enriched the types of long straight chain furanic compounds.By using XRD,XPS,FTIR,and SEM,the structure of the Na-Mn Ox was characterized in detail.Catalyst cycling experiments showed that the Na-Mn Ox can still maintain high activity after five cycles of recycling.Finally,founded on the analysis of previous work and experimental results,we analyzed and elaborated on the possible reaction mechanism.