Impact Of Air Pollution On Blood Routine Indexes Of Physical Examination Population In Shijiazhuang City

Objective:To investigate the impact of short-term exposure of six air pollutants(PM2.5,PM10,SO2,NO2,CO,O3)on blood routine indexes of physical examination population in Shijiazhuang.Methods:1.Study Population and Methods:The cross-sectional study was conducted in this paper to obtain the questionnaire and medical examination date of the physical examination population people in the three physical examination centers from April 1,2018 to December 31,2018(include all districts of Shijiazhuang).The questionnaire included age,sex,education level,work unit,smoking status,drinking status,exercise status,labor intensity,and so on.2.Pollutants and meteorological data:The air pollutants data during the study period,including daily pollutant concentration data of six pollutants(SO2?NO2?CO?O3?PM2.5?PM10)reported by 51 pollutant monitoring stations in Shijiazhuang,were from the Qingyue Open Environment Data Center.The meteorological data including average daily temperature and average daily relative humidity were from the China Meteorological Administration.3.Estimation of individual exposure to air pollutants:Used The ordinary kriging method to estimate the individual pollutant exposure concentrations.According to the date of the physical examination,the daily average of the short-term single-day lag(Lag0-Lag10)exposure concentration and the cumulative daily exposure concentration(Lag01-Lag010)of each pollutant before the survey were matched.4.Multiple linear regression was used to analyze the correlation intensity between pollutant and blood routine indexes,and conduct stratification analysis by sex,age and BMI.Regression analysis adjusted for temperature,relative humidity,sex,age,BMI,education level,smoking status,drinking status,exercise status,outdoor time,labor intensity,diabetes,dyslipidemia,family history of hypertension,use of antihypertensive drugs,and further analyzed the impact of gender on its relevance through gender stratification.All data analyses were performed using SPSS 18.0 software,with two sides significance level of 0.05.Results:1.Characteristics of the study population:A total of 5505 people was included in the study.The average age of the population is 43.3 ± 11.1 years and an average BMI is 24.19±3.41,3364 people are males(61.1%of the study population),2141 people are females(38.9%of the study population).Red blood cells,hemoglobin,average erythrocyte hemoglobin concentration,the percentages of white blood cells,lymphocytes,neutrophils,and eosinophils,The mean values of acid granules,percentage of basophils,percentage of monocytes,platelets,and average platelet volume are:4.76 ±0.47×1012/L,143.26 ± 17.07g/L,326.95 ± 17.71g/L,6.10 ± 1.52×109/L,34.19± 7.46(%),56.46 ± 7.97(%),2.23±1.80(%),0.57±0.27(%),7.04±1.67(%),242.67± 58.38×109/L,8.95±1.21F1;2.Situation of air pollution:During the study period,the measured daily average concentrations of PM2.5,PM10,SO2,NO2,CO,O3 reported by stations is 68.0,133.4,21.6,42.0,1076.8,83.8?g/m3,respectively;3.Individual exposure estimates:On the day of the physical examination,the average concentration of PM2.5?PM10?SO2?NO2?CO?O3 in the total population estimated by ordinary kriging method is 66.5?131.4?19.3?45.7?1100?83.6?g/m3,the average temperature is 16.9? and the average relative humidity is 54.6%;4.Impact of air pollutant exposure on blood routine indexes:(1)Correlation between PM2.5 short-term exposure and blood routine indexes:Short-term exposure to PM2.5 positive correlates with red blood cell count,average hemoglobin concentration,hemoglobin content,neutrophil percentage,and platelet count.Except that the platelet count had the strongest correlation on the 9th day of accumulation,all others on the 10th day of accumulation,the correlation is strongest.For every 10?g/m3 increase in PM2.5,the red blood cell count increased by 0.013×1012/L,the average hemoglobin concentration increased by 0.375g/L,and the hemoglobin content increased by 0.468g/L.The percentage of neutrophils increased by 0.143%,and the platelet count increased by 0.152×109/L.Short-term exposure to PM2.5 negative correlates with the percentage of lymphocytes,the percentage of eosinophils,the percentage of basophils,and the average platelet volume.The correlation was strongest on days 8,8,10,and 7.For every 10 ?/m3 increase in PM2.5,the percentage of lymphocytes decreased by 0.161 percentages,the percentage of eosinophils decreased by 0.009 percentages,and basophils The percentage of cells decreased by 0.045%,and the average platelet volume decreased by 0.059F1.Further stratification analysis shows that short-term exposure to PM2.5 has a stronger association with average hemoglobin concentration,hemoglobin content,lymphocyte percentage,neutrophil percentage,eosinophil percentage,and average platelet volume in males;it has a stronger association with red blood cell counts and platelet count in female;(2)Correlation between PM10 short-term exposure and blood routine indexes:Short-term exposure to PM10 positive correlates with red blood cell count,average hemoglobin concentration,hemoglobin content,neutrophil percentage,and platelet count.Except that the percentage of neutrophils is on the 9th day of the lag,and the platelet count is on the 8th day of the accumulation,the others are the most relevant.On the 10th day of accumulation,the correlation was the strongest.For every 10?g/m3 increase in PM10,the red blood cell count increased by 0.005 × 10/L,the average hemoglobin concentration increased by 0.203 g/L,the hemoglobin content increased by 0.174g/L,and the neutral granules The percentage of cells increased by 0.072%,and the platelet count increased by 0.055×109/L.Short-term exposure to PM10 negative correlates with the percentage of lymphocytes,eosinophils,basophils,and average platelet volume.The correlation is strongest on the 9th lag,the 5th lag,and the 6th cumulative day.For every 10?g/m3 increase in PM10,the percentage of lymphocytes decreased by 0.060%,the percentage of eosinophils decreased by 0.018%,and the percentage of basophils The percentage decreased by 0.020%and the average platelet volume decreased by 0.015F1.Further stratification analysis shows that short-term exposure to PM10 has a stronger association with average hemoglobin concentration,hemoglobin content,percentage of lymphocytes,percentage of neutrophils,percentage of eosinophils and percentage of basophils in males;it has a stronger association with Platelet counts in females;(3)Correlation between SO2 short-term exposure and blood routine indexes:Short-term exposure to SO2 positive correlates with red blood cell count,average hemoglobin concentration,hemoglobin content,neutrophil percentage,platelet count,and average platelet volume.Except that the percentage of neutrophils is the strongest on the 9th day of the lag,the others are accumulating on the 9th day,the intensity of correlation is the largest.For every 10?g/m3 increase in SO2,the red blood cell count increases by 0.058×1012/L,the average hemoglobin concentration increases by 2.907g/L,the hemoglobin content increases by 0.892g/L,and the percentage of neutrophils increases by 0.493 Percentage,platelet count increased by 0.278 ×109/L,and average platelet volume increased by 0.300F1;Short-term exposure to SO2 negative correlates with white blood cell count,eosinophil percentage,and basophil percentage,respectively on the 10th day of accumulation and the 9th lag.The correlation intensity was the largest on day 9 and lag day 9.For every 10?g/m increase in SO2,the white blood cell count decreased by 0.218×109/L,the percentage of eosinophils decreased by 0.182%,and the percentage of basophils decreased by 0.160%.Further stratification analysis shows that short-term exposure to SO2 has a stronger association with average hemoglobin concentration,hemoglobin content,white blood cell count,neutrophil percentage,eosinophil percentage,and basophil percentage in males;it has a stronger association with red blood cell count and platelet count in females;(4)Correlation between NO2 short-term exposure and blood routine indexes:Short-term exposure to NO2 positive correlates with red blood cell count,average hemoglobin concentration,hemoglobin content,neutrophil percentage,and platelet count.Except for hemoglobin content on the 8th day of accumulation and platelets on the 7th day of accumulation,the correlation intensity was the highest on the 10th day.The intensity was the largest.For every 10?g/m increase in NO2,the red blood cell count increases by 0.028×1012/L,the average hemoglobin concentration increases by 0.664 g/L,the hemoglobin content increases by 0.987 g/L,and the percentage of neutrophils increases by 0.277 percentages.The platelet count increased by 0.358×109/L;Short-term exposure to NO2 negative correlates with the white blood cell count,the percentage of lymphocytes,the percentage of eosinophils,and the percentage of basophils,respectively on the 10th day of accumulation,the 10th day of accumulation,and the 7th day of lag On the 9th day after the lag,the intensity was the largest.For every 10?g/m3 increase in NO2,the white blood cell count decreased by 0.037×109/L,the percentage of lymphocytes decreased by 0.276 percentages,the percentage of eosinophils decreased by 0.011 percentages,and the percentage of basophils Reduced by 0.055 percent.Further stratification analysis shows that short-term exposure to NO2 has a stronger association with average hemoglobin concentration,hemoglobin content,lymphocyte percentage,neutrophil percentage,eosinophil percentage,and average platelet volume in males;it has a stronger association with red blood cell counts and platelet counts in females;(5)Correlation between CO short-term exposure and blood routine indexes:Short-term exposure to CO positive correlates with red blood cell count,average hemoglobin concentration,hemoglobin content,and neutrophil percentage.The correlation intensity was greatest on the 10th day of accumulation,8 days of lag,9th day of accumulation,and 10th day of accumulation,For every 10?g/m3 increase in CO,red blood cell count increased by 0.0011×1012/L,mean hemoglobin concentration increased by 0.017g/L,and hemoglobin content increased by 0.051 g/L;Short-term exposure to CO negative correlates with lymphocyte percentage,eosinophil percentage,and basophil percentage Relevant,except that the average platelet volume had the highest correlation intensity on the 7th day of accumulation,and the other had the highest correlation intensity on the 10th day of accumulation.For every 10 ?g/m3 increase in CO,the percentage of lymphocytes decreased by 0.020%and the percentage of eosinophils decreased by 0.003.The percentage and the percentage of basophils decreased by 0.0037%,and the average platelet volume decreased by 0.008F1.Further stratification analysis shows that short-term exposure to CO has a stronger association with hemoglobin content,percentage of lymphocytes,percentage of neutrophils,percentage of eosinophils,average platelet volume in males;it has a stronger association with red blood cell counts in females;(6)Correlation between O3 short-term exposure and blood routine indexes:Short-term exposure to O3 positive correlates with mean hemoglobin concentration,lymphocyte percentage,eosinophil percentage,basophil percentage,platelet count,and average platelet volume.The correlation is strongest on day 5 of lag,day 7 of accumulation,day 1 of accumulation,day 2 of lag,day 9 of accumulation,and day 9 of accumulation.For each 10 ?g/m3 increase in O3,the average hemoglobin concentration increased by 0.102g/L,lymphocyte percentage increased by 0.141%,eosinophil percentage increased by 0.023%,basophil percentage increased by 0.004,platelet count increased by 0.278×109/L,and average platelet volume increased by 0.061F1;Short-term exposure to O3 negative correlates with red blood cell count,hemoglobin content,white blood cells,neutrophil percentage,and monocyte percentage.The correlation is strongest on the 10th day of lag,the 8th day of accumulation,the 6th day of accumulation,the 10th day of accumulation,and the first day of lag.For each 10ug/m3 increase in exposure concentration,the red blood cell count decreased by 0.004×1012/L,and the hemoglobin content decreased by 0.347g/L.The white blood cells decreased by 0.016×109/L,the percentage of neutrophils decreased by 0.063%,and the percentage of monocytes decreased by 0.023%.Further stratification analysis shows that short-term exposure to O3 has a stronger association with hemoglobin content,white blood cells and their number of classifications,and average platelet volume in males;and it has a stronger association with platelet counts in females.Conclusions:1.In the short-term exposure to PM2.5,PM10,SO2,NO2 and CO is associated with increased red blood cell and platelet;decreased percentage of lymphocytes percentage,percentage of eosinophils,percentage of basophils.2.In the short-term exposure to O3 is associated with increased lymphocyte percentage,eosinophil percentage,basophil percentage and platelet;decreased red blood cell and white blood cell.3.Short-term exposure to air pollution is associated with the blood routine indexes of the population,there were lagging and cumulative effects,and may be more strongly associated with females.