Preparation Of PPDO/PLGA/PES-b-PGA Blends And Their Chemical Environment Simulation In Vitro Degradation And Biocompatibility Study

In this paper,a desirable material for thoracic surgery hemostatic clips was prepared by melt blending.The two biodegradable polymer materials polydioxanone?PPDO?and poly?lactic-co-glycolic acid?copolymer?PLGA?were blended as a blending material that had combined the different performance advantages of the two materials by melt blending.The co-polymer of poly?ethylene succinate-co-glycolide?was prepared by a ring-opening copolymerization reaction in which polyethylene succinate?PES?as a macro-initiator reacted with glycolide?GA?monomer.The co-polymer of?PES-b-PGA?was used as a compatibilizer for PPDO and PLGA to enhance interface strength and to improve performance stabilities.The details are as follows:1.PPDO and PLGA were blended by melt blending to prepare a blending material of PPDO/PLGA.The thermal properties of the blending material and the compatibility of the two materials were investigated by TGA,DSC and SEM.2.Polystyrene glycol?PES?was used as a macro-initiator,glycolide?GA?was used as a reactive monomer,and stannous octoate?Sn?Oct?₂?was used as a catalyst to carry out bulk ring-opening copolymerization to prepare PES-b-PGA,which was used as a compatibilizer.It was characterized by IR,NMR and DSC to prove the chemical structure and explore the related thermal properties and crystallization properties.3.PPDO,PLGA and PES-b-PGA were blended by melt blending to prepare the blending material of PPDO/PLGA/PES-b-PGA.The blending material was characterized by TGA,DSC and SEM,which proved the compatibilizing effect of the compatibilizer on the two materials and obtained the best feed ratio.4.In order to study the degradation behavior of blended materials and to determine whether they were biocompatible.We used in vitro simulated degradation experiments and the biological histocompatibility experiments of in vitro cytotoxicity experiments and subcutaneous implantation experiments to PPDO/PLGA/PES-b-PGA blends.The results show that the degradation cycle of the blended material is consistent with the wound healing time,and the blended material will not affect the cell proliferation.At the same time,the implantation of the material will not adversely affect the wound healing and the tissue surrounding the implant site,which indicate the blended material has good biocompatibility.