Study On Radical Reactions To Construct Sulphones And Isatins

This thesis is mainly divided into two parts.The first part briefly reviews the research progress of difunctionalization of alkenes to construct C-S.It includes two aspects:(1)difunctionalization of olefin to synthesize sulfide compounds;(2)difunctionalization of olefin to synthesize sulfone compounds.The second part introduces the research on difunctionalization of olefins to construct sulfones and autooxidation of glycine derivatives to construct isatins respectively during my master's degree.1.The part details the visible light-induced sulfonylation and carbonyl sulfonylation reactions of olefins.The reaction employs TosMIC as the sulfonylation reagent to achieve the construction of ?-carbonylsulfone and ?,?-unsaturated vinylsulfone.The strategy provides an alternative protocol to construct C-S bonds in pharmaceutical industry and organic synthesis.2.The part details the auto-oxidation-induced intramolecular annulation tandem reaction of glycine derivatives to constrct isatins.This transformation provides a metalfree protocol for the preparation of isatin derivatives,which are important structural motifs widely found in organic molecules with various functions and privileged units for the synthesis of complex heterocycles.The reaction proceeds smoothly under mild reaction conditions and requires only Br?nsted acid and oxygen.