The Preparation Of Different Size Of Electrosprayed Microspheres Loaded With Drugs And Their Release Properties In SAIB Depot

In biomedical research,electrospinning materials have been used more and more widely,but even when drugs are loaded in osteogenic materials,there is still an obvious drug burst release and it is difficult to achieve long-term controlled release.Drug burst release tends to cause high drug concentration in the early stage to produce drug toxicity,while in the later period,the pesticide effect is lost due to low drug concentration,which is not conducive to bone formation.As a local drug delivery device,the microsphere / depot can effectively reduce the drug burst release and prolong the drug release time,and its drug release behavior can be regulated and controlled by changing the contents of the depot.In this study,the polymer solution made by PLGA,PEG and Ng dissolved in chloroform were mixed and magnetically stirred,and different size of naringin-loaded microspheres were produced by adjusting the electrospinning parameters.The size and morphology of electrospinning microspheres were observed with SEM and POLSCOPE,and the effect of particle size on physicochemical properties and drug release properties were measured.The results showed that different size of electrospinning microspheres were produced.The temperature and humidity range were 22? ~ 23? and 30 ~ 31% RH,and small electrospinning microspheres were produced with a slower flow rate of 0.030 mm/min,a voltage of 22 kV and a working distance of 20 cm,while the parameters for the large electrospun microspheres were 0.120 mm/min,18 kV and 15 cm.Both the small and large microspheres showed good monodispersity and smooth surface.After adding them into the SAIB depots,the drug release rate of the small microsphere group decreased from 68.79% to 3.30% on the first day,and the large microsphere group decreased from 63.20% to 0.00% on the first day.During the 92 days release process,the drug release rate of large microspheres / SAIB depot has been always lower than that of small microspheres / SAIB depot.These results demonstrated that different size of drug-loaded electrospinning microspheres could be fabricated with PLGA / PEG by regulated the electrospinning parameters.The microspheres / SAIB depots exhibited good initial controlled release and long-term sustained release capabilities.Different sizes of electrospinning microspheres showed different characteristics and the drug release behavior can be adjusted by changing the size of the microspheres.