Synthesis And Its Performance Of Hyperbranched Polythioether Microspheres

In recent years,hyperbranched polymer microspheres drawn the attention of the researchers,and one kind of hyperbranched polymer microspheres,hyperbranched polythioether microspheres,with superior performance stood out.but presently,the research of hyperbranched polythioether and hyperbranched polythioether microspheres are relatively few.In this article,we reported a newly way of synthesis to prepare hyperbranched polythioether microspheres by UV light click reaction and self-assembly,and explored its applications in the field of environment and biology,the research content is as follows:?1?Monomer containing disulfide bond and alkene was synthesized by lipoic acid?LA?and hydroxyl ethyl acrylate,then reducted to make disulfide bond rupture into two thiols,after that,the restored product was self-assembly into hyperbranched polythioether?HPDLA?microspheres with alkene for the core under the appropriate ratio of solvent and UV light,meanwhile platinum nanoparticles was added into HPDLA.Fourier Transform Infrared Spectroscopy?FTIR?,Nuclear Magnetic Resonance?NMR?and X-ray Photoelectron Spectroscopy?XPS?analysis shows that the HPDLA was synthesized successfully,Scanning Electron Microscope?SEM?and Dynamic Light Scattering?DLS?demonstrated that the morphology of HPDLA microspheres is at around 200 nm with spherical size,transmission electron microscopy?TEM?and energy disperse spectrometer?EDS?determines that the platinum nanoparticles was loaded in HPDLA microspheres.In addition,uv-vis spectra shows that Pt-HPTLA microspheres could catalyze 4-nitrophenol completely in 12 minutes with a ratio of 2:3,which was turned out to be an effective catalyst.?2?The lipoic acid?LA?and propiolic alcohol was put together for the target monomer with disulfide bond and alkyne,reduction reaction by DTT was followed for the thiol groups.Then the restored product was self-assembly into hyperbranched polythioether?HPTNHLA?microspheres with alkyne for the core under the appropriate ratio of solvent and UV light,at the same time curcumin was added into HPTLA microspheres.FTIR,NMR analysis shows that the HPTLA synthesized completely,SEM and DLS demonstrated that the morphology of HPDLA microspheres is spherical with the dimension about 200 nm-300 nm,then the dimension decreased to 80 nm-100 nm after reductant DTT worked in 100 h,UV-vis and Fluorescence Emission Spectra?PL?data showed that curcumin was successfully loaded in HPTLA microspheres.Subsequently,the drug release experiment was conducted under the conditions of buffer solution in pH=7.4 and pH=5.0,and the release amount of curcumin at 100 h was 90%and 65%respectively.?3?Using lipoic acid?LA?and propiolic amine were put together to form the structure with end of disulfide bond and alkyne by amidation reaction,reduction reaction by DTT was followed for the two thiol group.Then the restored product was self-assemble into microspheres with alkyne for the core of hyperbranched polythioether?HPTNHLA?microspheres.At the same time,the Fe₃O₄ nanoparticles were loaded in HPTNHLA,then introduced silver nanoparticles into magnetic microspheres by low wattage UV light.FTIR,NMR and XPS analysis shows that the HPTNHLA was synthesized successfully,TEM and Magnetometer?VSM?,X-ray Diffraction?XRD?and DLS demonstrates that the morphology of HPTNHLA microspheres is at around 250 nm,moreover it determined the Fe₃O₄ and silver nanoparticles loaded in HPTNHLA microspheres with superparamagnetism.In addition,UV-vis proves that Ag-Fe₃O₄-HPTNHLA microspheres could fully catalyze4-nitrophenol in 20 minutes with a ratio of 1:2,confirming that it was an efficient magnetic catalyst.