Antibiotic Active Pharmaceutical Ingredients' Exposure Assessment And Management Study For Waste Water Of Pharmaceutical Industry

Active pharmaceutical ingredients(APIs)in Environment has been frequently detected and widely concerned in recent years.During antibiotic pharmaceutical industry production,manufacturing and packaging process of pharmaceutical company,direct or indirect discharge of APIs from site wastewater treatment plant(WWTP)is one of the important approach.So t is necessary for antibiotic pharmaceutical company to take the assessment and reinforce the management for APIs discharging into environment.As the needs of APIs exposure management in environment,the paper put forward the general process to establish APIs' exposure criteria,establish 20 antibiotic explosure criteria,we suggest pharmaceutical company for the APIs engineering and management control,must classify management based the degree of risk,and apply for exposure criteria to make the actual application for tylosin and penicillin,the result is: via the Predicted No Effect Concentration(PNEC)of aquatic organism's standard testing species,it means the results that standard testing species' toxicity endpoint data divide uncertain factor can be pharmaceutical company's aquatic organism control criteria.By the exposure criteria actual application for one antibiotic pharmaceutical enterprise APIs discharge,the result shows: if emission data is lower than control criteria,it means pharmaceutical company has good management and control for APIs.On the contrary,if emission data is higher than control criteria,the antibiotic pharmaceutical company need take proper engineering and management control measures to reduce emission concentration in process wastewater to meet with control criteria requirements.In addition,in site management practices of APIs,secondary pollution problems of APIs are maximum ecological safety hazard,antibiotic pharmaceutical company need analyze whether(APIs)can generate secondary polutants based on designated process during wastewater treatment.If the decomposition product has lost the activity,the pharmaceutical company only need control their original(APIs).Otherwise,if it still is active,the pharmaceutical company need control and manage both original(APIs)and its decomposition product.Based on research for United States and European Union relative regulations or legislations system,the paper suggests our country can combine with our current situation,to establish designated regulations or legislations,begin antibiotic pharmaceutical active ingredients discharge and environment exposure management legislations establishment work as soon as possible.We suggest that we can classify all pharmacies into different classes.For pharmacies of Hormones,parasiticides,carcinogenic,mutagenic,teratogenic or reproductive toxicity,they can be defined as high risk for aquatic organism;other pharmacies can be defined as lower risk.High-risk pharmacies must have mandatory regulations or legislations requirements.Low-risk pharmacies have partial mandatory legislations requirements,and partial recommended legislations requirements to manage and control.Then we can keep classification management for different risk pharmaceutical company,maximum reduce high-risk pharmacies impact for aquatic organisms.At the same time for low-risk pharmacies,we have partial mandatory legislations requirements,and partial recommended legislations requirements to manage by limited resource and lower cost,and make it available for APIs management.