Synthetize Of FePd Decorated Carbon Nanotubes And Their Radiosensitization

Radiotherapy is one of the most important tumor treatment methods at present.For decades,the technology and equipment of radiotherapy have achieved tremendous development.However,the disability in distinguishing normal tissues from tumor tissues has always been a problem that needs to be resolved in radiotherapy.In order to make more serious destruction to tumor tissues without increasing the exposure dose of normal tissues,we should look for efficient radiosensitizers to improve the radiosensitivity of tumors to radiation.Advances in nanomedicine have offered innovative strategies to improve chemoradiotherapy.In this study,we combined the advantages of two different nanomaterials,iron-palladium nanoparticles and carbon nanotubes,designed and synthesized the iron-palladium nanoparticles/carbon nanotube(FePd@CNTs)nanocomposite by chemical reduction.The materials were characterized by transmission electron microscopy,powder X-ray diffraction,Fourier infrared spectroscopy and photoelectron spectroscopy.The cytotoxicity of FePd@CNTs was evaluated using CCK8,experiments have shown that FePd@CNTs has low cytotoxicity at low concentrations.The live/death staining experiment of grouping treated MCF-7 cells proved that FePd@CNTs has a good radiosensitization effect,and the colony formation experiment further confirmed this conclusion.Flow cytometry was used to evaluate the apoptosis of the cells,the results showed that the combined effect of FePd@CNTs and X-ray induced apoptosis to a great extent.The in vivo treatment effect was evaluated in tumor-bearing mice,FePd@CNTs combined radiotherapy clearly controlled the growth of the tumor and did not show a significant influence on the normal growth mice.Finally,fluorescent staining of the tumor slices revealed that FePd@CNTs combined with X-ray treatment produced more reactive oxygen species(ROS)in the tumor tissue.These results prove that FePd@CNTs has potential as a radiosensitizer.