Nickel-Catalyzed Redox-Neutral Remote Hydroarylation Of Olefins And Reductive Remote Hydroalkynation Of Olefins

The transition metal catalyzed migratory functionalization of olefins via alkene isomerization and sequential cross-coupling is a novel strategy for the functionalization of the distant sp~3 C–H bonds.Through this approach,isomeric mixture of olefins could be converted into value-added products under mild conditions in a regioconvergent manner.This thesis focuses on the nickel-hydride catalyzed remote hydrofunctionalization of alkenes.In the first part,we developed a nickel-catalyzed redox-relay migratory hydroarylation from alkenes and arylboronic acids.In the second part,we developed a nickel-catalyzed reductive migratory hydroalkynation from alkenes and alkynyl bromides.In the first chapter,we introduce the history of C–H activation and the transition metal-catalyzed hydrofunctionalization of olefins.And we summarize the development of metal-catalyzed hydroarylation of alkene as well as alkynation of sp~3 C–H bonds.In the second chapter,a redox-relay migratory hydroarylation of isomeric mixtures of olefins with arylboronic acids catalyzed by nickel complexes bearing diamine ligands is developed.In the third chapter,we achieved alkynation of remote sp~3 C–H bond via alkene isomerization and sequential alkynation.