Design Of A Hemostatic Clip For Surgical Operation And Study On In Vitro Degradation In The Chemistry Simulated Environment For PPDO/PGA Materials

In this essay,a more reasonable and more convenient hemostat clip is designed.The main materials are poly(para-dioxanone)and polyglycolide acid to make a blend by solution blending,which are as material for a hemostat clip.PDO and GA were used to prepare a compatibilizer to improve the compatibility of PPDO with PGA.The details are as follows:1.Solidworks program is used to design a sleeker hemostat clip in order to overcome the sharp.edge defects of the hemostat clip and the damage to normal tissue and cells in the process of surgical operation.2.PPDO and PGA were used as raw materials and PPDO and PGA were mixed by solution blending with hexafluoroisopropanol as solvent to prepare PPDO/PGA blends.Preparation of PPDO and PGA copolymer compatibilizer using PDO and GA as monomers The blend was investigated by FTIR,DSC,DTG,SEM and so on,and the results show that the compatibilizer is successfully prepared and the compatibility of PPDO/PGA blend can lbe improved effectively when adding the compatiblizer.3.In vitro degradation of the blend is carried out at 37 ℃.The results show that the degradation of the blends is the most slowly in the simulated human buffer solution.The time period of the in vitro degradation coincides with the healing time of the wound.However,the degradation is more rapidly either in physiological saline or in distilled water.This is because both physiological saline and distilled water are acidic,which can accelerate the degradation of the blend because.