Development Of A Fully Automatic Liquid Marble Microreactor Continuous Generator

The development of microreactor platforms is an emerging technology in the chemistry and biology.Compared with conventional reactions,microreactions can reduce the amount of reagents used,improve analytical performance,reduce instrument footprint,reduce unit cost,and simplify functional components.In addition,the microreaction system can perform multiple sets of experiments at the same time,which is the additional advantage of ultra high throughput.At present,microreactions usually use microchannels to achieve reaction miniaturization.Microfluids can controllably generate and manipulate microdroplets.However,the system is expensive to construct with high technical thresholds,Moreover,it requires professional operation,and is easily clogged during use.In particular,it deals with reactions with high viscosity or solid matter production.Liquid marble is a newly developed microreactor,which can control micro-droplets conveniently and quickly without being polluted by the external environment.It has a wide range of applications and simple operation.In this project,the fluid mechanics of liquid marbles and the process of droplet enveloping are deeply studied,and the liquid marbles based on vibrating discs are innovatively proposed.The system can achieve high-speed uniform wrapping of droplets(packing rate up to 350 pieces/min).In order to detect the quality of liquid marbles,the mechanism of liquid marble stability is explored,and a dynamic test platform and a static test platform are proposed innovatively.Among them,the high-flux dynamic test platform can perform impact test of 60 pieces/min and the high-precision static test platform can record the pressure of liquid marbles in real time(up to 0.5Pa).By using different types of hydrophobic particles for the liquid marbles fabrication and testing the stability of liquid marbles,the factors affecting the stability of liquid marbles are obtained.The designed automatic liquid marble microreactor continuous generation system consists of hardware circuit,mechanical structure and upper computer.A high-precision droplet generation module,vibration package platform and stability test systems are constructed and the PID algorithm is adopted to realize droplet fabrication with precise control of positioning.In addition,and the Visual Studio software is employed to write a human-computer interface.After the completion of the platform construction,each module is tested.The whole system can realize high-speed production of droplets,high parcel rate of 98%,continuous dynamic test of 16 liquid marbles,high-precision static test(0.5Pa),and design of different surfaces.The particle type was tested on the whole machine,and the qualified liquid marble can be successfully produced in a high speed.