| China is the world's largest producer and consumer of antibiotics,as well as one of the world's most severely resistant bacteria.At present,about half of the antibiotics in China as feed additives are widely used in livestock and poultry breeding,antibiotics have the role of preventing and controlling diseases,promoting growth,saving nutrition and so on.Because the supervision system is not perfect,driven by interests and other reasons,manufacturers and farmers in the use of antibiotics in the process of blind addition,abuse of antibiotics and other problems,and then lead to increased bacterial resistance,harm to human health,damage to environmental ecology and damage to the economy and other effects.Data show that the total annual production of antibiotics in China is about 210,000 tons,domestic consumption of about 180,000 tons,of which for the livestock and feed industry as high as 97,000 tons of antibiotics,accounting for about 54%.Antibiotic use has continued to rise in recent years,most of which is used as a feed additive rather than as a therapeutic drug.China has repeatedly detected antibiotic residues in a variety of edible meat products,dairy products and even animal-derived biochemical drugs,people long-term intake of a variety of antibiotic residues of excess animal products equivalent to long-term low doses of antibiotics,resulting in teratogenic,carcinogenic,mutagenic effects,therefore,pay attention to food safety issues,it is urgent.Since people found that antibiotics and other side effects on animals,but also to human health,the relevant experts and scholars at home and abroad have been looking for improvements and alternatives to Western medicine,so China's traditional natural veterinary medicine came into being.Ligustrum is native to China and is commonly cultivated in China.Ligustrum lucidum is the dry fruit of Ligustrum lucidum after ripening.It belongs to traditional Chinese herbal medicine of replenishing type,and it is a kind of traditional Chinese medicine for strengthening and strengthening foundation.It is rich in various nutrients and biological active substances.Test method: Choose 50 healthy du long large weaning piglets,randomly divided into 5 groups,each group of 10.The 5 groups were control group,Chinese herbal Medicine high,medium and low dose group and antibiotic group.The high,medium and low dose groups of privet added 2%,1% and 0.5% privet powder to the diet respectively,and the antibiotic group added gentamicin sulfate(1mg/kg)to the diet,and no drugs were added to the control group.(1)To study the effect of privet on the growth performance and blood routine of weaned piglets;(2)Privet is worth affecting the duodenal,jejunum,ileum intestinal villi height(VH),recess depth(CD)and VH/CD of Piglets,and(3)establish a model of piglet diarrhea to study the small intestine duodenal,jejunum and Ileum intestinal villi height(VH),recess depth depth(CD)and VH/CD are worth affecting;(4)The expression level of small intestine gene in piglets infected with Escherichia coli infection.Results:(1)2% privet and 1% privet could significantly reduce the weight ratio of piglets(P<0.05),2% of Privet had significantly increased the end weight of piglets(P<0.05),and there was a significant upward trend between WBC antibiotic group and low dose Group(P<0.05);There was a significant upward trend in the RBC control group compared with the middle dose Group(P<0.05);there was a significant upward trend in the MCV control group,low dose group and antibiotic group compared with the middle dose Group(P<0.05),and there was a significant upward trend in the MCH control group,low dose group and antibiotic group compared with the middle dose Group(P<0.05);The trend of significant decrease of dose group and control group in RDW-SD(P<0.05).(2)Duodenal: There was a significant difference between the VH control group and the high and Medium dose Group(P<0.05),there were significant differences between the low dose group and the high-dose group and the middle Dose Group(P<0.05),and there was a significant difference between the antibiotic group and the middle Dose Group(P<0.05);VH/CD Value Control group,There was a significant difference between the antibiotic group and the middle Dose Group(P<0.05);Jejunum: VH High,medium and low dose group and antibiotic group had a tendency to improve compared with the control group,but there was no significant difference(P>0.05);the remaining four groups in the CD high-dose group had a decreasing trend,but there was no significant difference(P>0.05);VH/CD value Privet High School lower three groups were higher than the control group and antibiotic group,but there was no significant difference(P>0.05).Ileum: There were significant differences in the VH control group than in the high,medium and low dose groups(P<0.05).(3)duodenal: The VH control group was significantly different from the antibiotic group in the high,medium and low dose groups(P<0.01);there were significant differences between the CD control group and the high and medium dose groups,and there were significant differences between the low dose group and the middle Dose Group(P<0.05);The VH/CD value control group was associated with high andThere were significant differences in the middle dose Group(P<0.01),and there was a significant difference between the low dose group and the middle Dose Group(P<0.05).There was a significant difference between the VH control group and the High Dose Group(P<0.05),and the control group of VH/CD value was significantly different from that of the high dose Group(P<0.05).After the attack,there was a significant difference between the VH control group and the High School(P<0.01),the low dose group was significantly different from the high and anti-resistance(P<0.01),the low dose group was significantly different from the middle dose Group(P<0.05),and the VH/CD value control group was significantly different from the high and Medium dose Group(P<0.05),There was a significant difference between the low dose group and the high and Medium dose Group(P<0.05).(4)The expression level of small intestine gene in piglets infected with Escherichia coli by fluorescence quantitative PCR can significantly reduce TNF-? and IL-1?.Conclusion: To sum up,privet can improve the production performance of piglets and improve liver and kidney function,improve the height of intestinal villi in piglets,reduce the depth of recess,and play a positive role in intestinal mucosal immunity. |
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