Application Of Low Dose Midazolam Combined With Sufentanil Intravenous Anesthesia In Bronchoscopy

Objective:The purpose of this study was to compare the sedative effect and hemodynamics of the combination of midazolam and sufentanil for fiberoptic bronchoscopy.Assess the patient's tolerance and satisfaction with the test.Methods:Collection 2015.11-2017.11 Wanjishan Hospital,Wannan Medical College Forty-three patients hospitalized for electronic bronchoscopy due to lung disease,aged 32-76 years old,of which 23 patients in the observation group were given 2%lidocaine topical anesthesia,and 5 minutes before surgery Intramuscular injection of midazolam 2 mg and sufentanil 5 ? g were given.During the bronchoscopy,midazolam 1-2 mg was added as appropriate.The rest was only given 2% lidocaine topical anesthesia as a control group.Before the electronic bronchoscopy was performed,written informed consent was signed.And monitor the blood pressure(BP),heart rate(HR),respiratory rate(RR),SPO2 and other vital signs before,during and after the examination,and during the examination,and through the microscopic examination score and OAA/S score.Evaluate the sedation effect during induction.The adverse reactions during the examination were recorded,and the patient was asked a questionnaire on satisfaction after bronchoscopy.Results:There were no significant differences in basic data such as age,gender,weight,height,and medical history between the two groups(P> 0.05).There were significant differences in bronchoscopy scores and OAA/S scores between the two groups(P<0.01).The control group was significantly higher than the observation group microscopic examination score(P=0.005).Compared with the control group(5.00 ± 0.00),the OAA/S score in the observation group(4.35 ± 0.93)was obviously lower.The analysis of vital signs at different time periods showed that before the examination,the vital signs of the two groups were similar,with no statistical significance(P>0.05).After bronchoscopy was started,the change of systolic blood pressure in the observation group was significantly lower than that in the control group,with statistical difference(P<0.01).Compared with the control group,the change of systolic blood pressure in the observation group after the examination was similarly low,with statistical difference(P=0.001).Diastolic blood pressure was statistically different between the two groups only when entering the glottis and examination(P<0.05).However,there was no significant change in the diastolic blood pressure of the observation group after the examination,and the difference was not statistically significant(P>0.05).The change of heart rate was different between the two groups when entering the glottis and the examination.The change of heart rate in the observation group was significantly lower than that in the control group(P<0.05).Obvious changes were observed in the observation group when entering the glottis.After the examination,there was no significant difference in heart rate between the two groups(P>0.05).Respiratory frequency of the observation group was significantly lower than that of the control group at the time of entering the glottis(P=0.034).The respiratory rate was the same in the two groups after the examination and examination.Before and after bronchoscopy,it was found that there was no significant difference in oxygen saturation of arterial blood between the two groups at different time periods(P>0.05),both fluctuating within the normal range.The incidence of adverse reactions such as cough,body movement and hernia in the observation group was low,and the difference was statistically significant(P < 0.05).After the fibrobronchoscopy,the satisfaction of the observation group was higher than that of the control group(P <0.01),while most of the patients in the control group were reluctant to repeat the bronchoscopy.conclusion:The use of low-dose midazolam combined with sufentanil intravenous anesthesia in bronchoscopy is safe,effective and can reduce patient discomfort,and is worthy of clinical use.