Study Of Resting State FMRI In Patients With GTCS And BECT

Objectives: Epilepsy is a common neurological disorder characterized by neuronal hypersynchronous abnormal discharges.Resting state functional magnetic resonance imaging(fMRI)combined with regional homogeneity(ReHo)and functional connectivity analysis methods can be used to observe the synchronization of cerebral neurons in epileptic patients and the influence of epileptic discharge on brain neuronal synchronization activity and brain network.To evaluate the value of ReHo and functional connectivity analysis methods in epilepsy research.Methods: In the department of neurology and pediatrics of the affiliated hospital of north sichuan medical university,23 cases of GTCS patients meeting the criteria for the proposed diagnostic scheme People with epileptic seizures and with epilepsy in ILAE(1989)were classified as GTCS group,and 22 cases of BECT patients matched with BECT group were recruited,and another 28 healthy volunteers whose age and sex and educational level matched were healthy controls.All subjects underwent neuropsychological assessment(in China revised wechsler intelligence scale for children).The 3.0T magnetic resonance scanner(GE Discovery MR750)was used for rs-fMRI data acquisition.The collected fMRI data were pretreated by NIT software,and then,REST software be used to calculate ReHo values.Statistical analysis was performed to analyze the differences in brain regions within and between the three groups,and the functional connectivity analysis was performed using the brain regions with the most obvious differences as seed points.(1)One-sample t-test results showed that the brain regions with high ReHo values were located in the medial frontal lobe,posterior cingulate gyrus,anterior cingulate gyrus,mid-temporal gyrus,putamen nucleus,lingual gyrus,precuneus,insular,postcentral gyrus,visual cortex,supplementary motor area and other regions.(2)After one-way analysis of variance was performed between the three groups,it showed significantly difference in ReHo values among left inferior temporal gyrus,left middle frontal gyrus,bilateral middle occipital gyrus and left frontal dorsomedial frontal gyrus(P<0.001,FDR check).(3)Analysis of functional connectivity of seed points in the above five brain regions,we found that both in GTCS group and BECT group the functional connectivity between left inferior temporal gyrus and left inferior temporal gyrus,right middle temporal gyrus,left middle frontal gyrus and left medial frontal gyrus,left middle occipital middle and right sacral pole,right occipital middle gyrus,right lingual gyrus,right occipital middle and left cerebella,cerebellar vermis,left suboccipital gyrus,right occipital middle gyrus,medial cingulate gyrus,left frontal gyrus,right cerebellum,right peripheral cortical fissure,the left central sulcus,the left superior frontal gyrus and the left medial cingulate gyrus were significantly abnormal,and there was a significant difference between the two groups of epilepsy patients(p<0.005).Conclusion:(1)Increased ReHo values in resting DMN brain regions and support for enhanced functional activity in DMN brain regions during rest may correlate with human spontaneous activity.(2)Resting state fMRI combined with ReHo and functional connectivity Results: analysis showed that the GTCS and BECT patients had abnormalities in multiple brain networks,including language-related networks,visual correlation networks,motor-related networks,DMN,etc.,possibly due to epileptic discharges disrupting normal brain function networks.(3)There are differences in brain function networks and connections between GTCS and BECT patients,which may be related to different types of epileptiform discharges,clinical manifestations,and prognosis.It is worth further study.