To Explore The Related Factors Of Acute Radiation Pneumonia After Radiotherapy In Patients With Lung Cancer

Background and ObjectiveTo explore the risk factors of acute radiation pneumonia in patients with lung cancer after receiving radiation therapy,guide the clinical effective prediction of the factors that may cause damage to the lungs of patients with lung cancer after radiotherapy,and take reasonable treatment measures according to the actual conditions of patients to prevent the occurrence of acute radiation pneumonia.Therefore,the effect of radiation therapy on lung cancer is improved,the complications are reduced,and the safety of radiation therapy is improved.Materials and methodsFrom January 2014 to January 2017,142 patients with lung cancer who underwent radiotherapy were selected as the subjects.Among them,34(23.94%)patients had acute radiation pneumonia after radiotherapy.The patients were divided into acute pneumonia group and normal radiotherapy group according to whether the patients were treated with acute radiation-induced pneumonia after radiotherapy.The patients were divided into acute lung group and normal radiotherapy group.The patients were divided into two groups according to the general information,condition,albumin,hemoglobin level and related treatment.And to analyze the factors that cause acute radiation pneumonia after radiotherapy in lung cancer patients.Logistic single factor and multivariate analysis of various factors were used to determine the risk factors of acute radiation pneumonia after radiotherapy in lung cancer patients.The data used in this study were analyzed by SPSS20.0 statistical software.For the percentage of the count data(%),the results of the comparisons between the data were tested using χ~2,with P<0.05 as the difference.Statistical significance;for the use of measurement data((?)±s)that the results of the comparison between the use of t to test,to P<0.05 for the difference was statistically significant.Univariate logistic regression model was used to analyze the risk factors of acute radiation pneumonia after radiotherapy in lung cancer patients.The odds ratio and the confidence interval(95%CI)were calculated with P<0.05 as the statistical standard.Results1.The incidence of lung cancer in the patients with acute lung pneumonia was history of smoking,history of chronic lung disease,diabetes mellitus,FEV1before chemotherapy(1S expiratory force)<2L,combined radiotherapy and chemotherapy,total radiotherapy>56Gy,MLD((P<0.05).The percentage of V5>40%,V20>25%,V30>18%was significantly higher than that of normal chemotherapy group(P<0.05).The difference was statistically significant(P<0.05).However,there was no significant difference in gender,age,clinical stage,pathological type,albumin and hemoglobin level between the two groups(P>0.05);2.The results showed that there were statistically significant differences in tumor location,smoking history,history of chronic lung disease,diabetes mellitus,preoperative FEV1,chemoradiotherapy combined with total radiotherapy,MLD,V5>40%,V20,V30 and so on.The total dose of radiotherapy was 56Gy,MLD>15Gy,V5>40%,V20>25%,and the incidence of chronic lung disease was compared with that of diabetes mellitus and FEV1<2L before radiotherapy.,V30>18%was associated with acute radiation pneumonia after radiotherapy in patients with lung cancer,P<0.05,and OR>1,and was a risk factor in the confidence interval(95%CI);3.Multivariate unconditional logistic regression analysis of multiple risk factors,middle and lower lung cancer,smoking history,history of chronic lung disease,diabetes mellitus,FEV1<2L before chemotherapy,combined radiotherapy and chemotherapy,total radiotherapy>56Gy,MLD>15Gy,V5>40%,V20>25%,V30>18%and acute radiation pneumonia after radiotherapy,P<0.05,and OR>1,and in the confidence interval(95%CI),is an independent risk factor.Conclusion1.The occurrence of acute radiation pneumonitis after radiotherapy in patients with lung cancer is closely related to the patient’s tumor location,living habits,history of illness,and treatment.2.Before radiotherapy for lung cancer patients,we must comprehensively assess general patient data,disease history,and treatment history.According to the actual conditions of patients,develop individualized radiotherapy programs to reduce the risk of acute radiation pneumonitis after radiotherapy and improve treatment safety.And effectiveness.