| Objective:Discuss the clinical characteristics of endometriosis-associated ovarian carcinoma,to analyze the clinical significance on malignant transformation.Methods:Patients with endometriosis-associated ovarian cancer were treated in Qilu Hospital of Shandong University from January 2010 to December 2017.The clinical data of the 32 patients is collected for research group and contemporary 64 patients diagnosed ovarian serous cystadenocarcinoma as control group.The clinical features including age,menstruation,fertility,pathological pattern,clinical manifestations,treatment and prognosis are analyzed.SPSS23.0 software was used to analyze the data.For each analytical test method,P<0.05 was considered as the standard of statistical significance.Results:1.Age,menstruation and fertility:the mean age and average menarche of EAOC group were 46.34±9.42,13.52±1.64;the mean gravidity and parity were 2.33±1.51,1.33±0.89;all above is statistically different with the control group(P<0.05).2.Pathological patterns:the most common were CCC(17/32)and EAC(15/32)rooted on this research.3.Side of malignant ovary and EMs outside ovaries:EAOC is predisposed to single ovary and incorporative EMs outside ovaries are more common than,which are both statistically different with the control group(P<0.05).4.FIGO stages and grades:the stage of EAOC was tend to be earlier as stage I more often;its differentiated degree was usually gradel.Both of them are statistically different with the control group(P<0.05).5.Clinical presentation:the major presentations were abdominal pain(14/32),ventosity(10/32),vaginal bleeding(6/32),pelvic mass(7/32)and ascites(1/32).Percent of abdominal pain is higher compared with the control group.6.CA125:the distribution interval of CA125 is concentrated on 35-200U/ml,which is less than mean level of control group,the difference is significantly statistical(P<0.05).7.Diagnosis:32 were diagnosed as pelvic mass and merely 4 ascites were found through ultrasound and CT.EAOC wouldn’t be distinguished from the ovarian serous adenocarcinoma by the size,nature and site of the pelvic mass reflected on the image of ultrasound and CT.8.Partial complications:the major complications were 12 non-malignant EMs and 4 endometrial cancer,which both were statistically different(P<0.05).9.Treatment and prognosis:All 32 patients of EAOC went through the surgery,of which 27 came up to the standard of ideal CRS and 31 received chemotherapy after the surgery.Followed-up 31 patients had a mean DFS-28.97±12.21 months and their recurrence rate and mortality respectively are 32.26%、3.23%.Conclusions:1.The mean age of onset with EAOC is earlier than the ovarian cystadenocarcinoma.2.The most common pathological patterns were CCC and EAC.3.EAOC tend to perform early FIGO stage and high grade.4.EAOC is dormant lacking in specific clinical characteristics.5.Ultrasound and CT may be meaningful on early diagnosis and CA125 may increase indistinctively.6.The EAOC patients can receive a ideal surgery and sensitive chemotherapy so as to attain a better prognosis. |
