Comparison And Correlation Analysis Of Adverse Reaction Of Different Asparaginase In Children With Acute Lymphoblastic Leukemia

Leukemia is a monoclonal and heterogeneous malignant disease caused by the malignant proliferation of hematopoietic cells at a certain stage in normal hematopoiesis.Studies at home and abroad have pointed out that the incidence of childhood leukemia is about?3⁴?/10⁵,of which acute leukemia incidence of the first,accounting for 90%⁹5%.Acute leukemia and acute lymphoblastic leukemia the most common,accounting for the incidence of 75%⁸5%,followed by acute myeloid leukemia^[1].In recent years,with the improvement of molecular biology,genetics and immunology,the pathogenesis and mechanism of some types of leukemia have been basically clarified.Studies have shown that common causes of leukemia are inherent factors,infection,physical and chemical factors,the conversion of other hematological diseases,etc.^[2].Child ALL has become one of the most clinically curable childhood malignancies,of which combination chemotherapy is still the first choice for newly diagnosed ALL children^[3].Asparaginase preparations have been used in clinical for more than 30 years,which runs through the entire chemotherapy in children with ALL,as clinical first-line medication,since the clinical application of asparaginase preparations have undergone a series of development,L-asparaginase is an important component of multidrug therapy for childhood acute lymphoblastic leukemia^[4].PurposeComparison of coagulation and allergic responses between pegaspargase and L-asparaginase in induced remission in children with acute lymphocytic leukemia The difference between the incidence of acute pancreatitis,provides the theoretical guidance for the selection of the appropriate type of asparaginase preparations for children with acute lymphoblastic leukemia combined with chemotherapy regimens,and is monitored by clinicians when using asparaginase preparations.Adverse reactions,take timely and effective response to provide guidance.Materials and MethodsRetrospectively collected clinical data from 108 children with ALL?PEG-asp and L-asp?who were treated with PEG-asp or L-asp for induction of remission chemotherapy in the Department of Pediatric Hematology from June 2013 to January2017 data.On day 33 after induction of remission,bone marrow findings showed that both groups were in complete remission(MRD<10^-4).ResultsIn the PEG-asp group,fibrinogen decreased 65 times,the activated partial thromboplastin time prolonged 25 times,and the L-asp group reduced fibrinogen 33times,the activated partial thromboplastin time prolonged 3 times;1 case of anaphylactic reaction in PEG-asp group;2 cases of allergic reaction in L-ASP group;1 case of acute pancreatitis in PEG-asp group;1 case of acute pancreatitis in L-asp group Times.ConclusionThe abnormal coagulation function induced by PEG-asp and L-asp showed a decrease in FIB and prolongation of APTT,and there was a statistically significant difference between the two groups in the coagulation dysfunction.There was no statistical difference in the incidence of allergic reactions and pancreatitis.