Study The Effect Of Human Cytomegalovirus Infection On Development Of Global Developmental Delay Infant

Objective: To study the effect of human cytomegalovirus(hCMV)infection on global developmental delay infant’s hearing,intelligence and motor development.Menthods: Choosing 124 global developmental delay(GDD)infants treated at the Pediatric Neurological Rehabilitation Center from January 2015 to January 2018,The copies of hCMV DNA in the urine of 124 infants was assessed by seneory and quantitative PCR.Based on the test results,we found that 60 infants of hCMV infected and 64 uninfected infants.The hearing results were measured with brainstem auditory evoked potential(BAEP),intelligence were assessed with Gesell developmental scale,the gross motor function were assessed with Gross motor function measure(GMFM)scale with 88 items,the fine motor function were assessed with Fine motor function measure(FMFM)scale,and analyzed the differeces between the two groups.Results: BAEP testing showed 43 infected infants(77 ears)had hearing disorders,accounting for 71.67% of the total number of the infected group,while 22 uninfected infants(42 ears)had hearing disoeders,accounting for 34.38% of the total number of the uninfected group,the difference between the two groups was significant(P<0.05);the developmental quotient of the Gesell developmental scale in infected infants was(67.70±7.59)compared with(72.48±4.24)in uninfected infants,the difference between the two groups was significant(P<0.05);the mean score of the Gross motor function measure scale in infected infants was(23.670±25.523)compared with(38.190±49.496)in uninfected infants,the difference between the two groups was significant(P<0.05);the mean score of the Fine motor function measure scale in infected infants was(20.680±17.049)compared with(22.500±23.654)in uninfected infants,the difference between the two groups was little significant(P>0.05).Conclusions: 1.hCMV infection could aggravate hearing disorders,intelligence development delay and gross moter development delay on global developmental delay infants.2.hCMV infection mainly induce mild and moderate hearing disorders.