Study On 10-year Cardiovascular Disease Risk In Patients With Schizophrenia

Objective:Schizophrenia is a chronic mental illness and it has a high mortality rate.In addition to unnatural deaths(e.g.accident,homicide,or suicide),the leading cause of excess mortality in schizophrenia patients is physical illness,including neoplastic disease,respiratory disease,and cardiovascular disease(CVD).Among them,schizophrenia with cardiovascular disease is the main reason for the increase in mortality in schizophrenic patients.The Framing-ham risk score(FRS)is a well-known gender-specific multivariable risk factor algorithm,which uses a dangerous hierarchy instead of a continuous variable,Calculating the risk of coronary heart disease and the risk of individual cardiovascular events in the next 10 years,based on cholesterol and non-cholesterol factors.In this study,the risk of cardiovascular disease in Chinese schizophrenic patients was assessed by Framing-ham risk score,which provided the theoretical basis for alleviating the burden and prevention of cardiovascular disease in Chinese schizophrenic patients.Methods:466 cases of schizophrenia patients were randomly analyzed,including body mass index(BMI),Fasting blood glucose(FBG),triglyceride(TG),,total cholesterol(TC),smoking rate(smoking people/total people),Framing-ham Risk Score(FRS),high density lipoprotein-cholesterol(HDL-C)and age of the vessel(VA)and comparing with the 507 healthy controls.The 10-yearcardiovascular risk(FRS)and age of the vessel(VA)were assessed using the Framing-ham Risk Score.Results Patients with schizophrenia in the next 10 years the risk of cardiovascular disease than the control group[(6.71±6.95)%vs.(4.76±3.07)%],the difference was statistically significant(P<0.05).Comparing with the control group,smoking prevalence[(41%)vs.(19%)],MS[(25%)vs.(17%)],BMI[(23.67±3.61)kg/m~2vs.(21.73±4.11)kg/m~2]and VA[(46.7±15.3)vs.(43.7±9.8)]in patients group were higher than the healthy controls.SBP[(119.86±14.90)mmHg vs.(128.10±15.41)mmHg]and HDL-C[(1.08±0.27)mmol/L vs.(1.38±0.22)mmol/L]were lower than the healthy controls.The FRS score of the patient group was positively correlated with BMI,FBG level and SBP,waist circumference and smoking index(P<0.05)and was negatively correlated with the levels of HDL-C.Multivariate Linear Regression analysis demonstrates that FRS was correlated with FBG(β=0.181,P<0.01)、SBP(β=0.149,P<0.01)、HDL-C(β=-0.107,P<0.01)and smoking index(β=0.554,P<0.01).Conclusion The risk of cardiovascular disease in patients with schizophrenia over the next 10 years was 6.7%,significantly higher than the control group.Fasting blood glucose,systolic blood pressure,high density lipoprotein,smoking may be associated with schizophrenia patients in the next 10 years associated with cardi ovascular disease.