Clinical Analysis Of Post-stroke Epilepsy

Objective: To investigate the clinical features and risk factors of secondary epilepsy after stroke.The relationship between blood pressure and other comorbidities and post-stroke epilepsy at admission was studied.Review literature on post-stroke epilepsy research in recent years to explore new knowledge about post-stroke epilepsy(including epidemiology,pathogenesis,clinical features,treatment,etc.).Methods: A total of 228 patients with cerebral stroke and post-stroke epilepsy who were admitted to the Department of Neurology,Second Affiliated Hospital of Soochow University from June 2014 to June 2017 were collected.The clinical data were analyzed retrospectively to analyze post-stroke epilepsy.Relationship with age,sex,stroke site,hypertension,diabetes,pulmonary infection,and blood pressure levels during stroke.This study used logistic regression models to analyze the effect of blood pressure and other clinical confounding factors(age,sex,diabetes,stroke type,stroke site,hypertension,and lung infection)on post-stroke seizures at admission.RESULTS: High age,low or normal blood pressure at admission,cortical stroke,and stroke combined with pulmonary infection were significantly associated with epilepsy after stroke(P<0.01,P<0.001,P<0.001).Logistic regression analysis showed that low blood pressure(or normal blood pressure)during stroke,lung infection with stroke,and stroke in the cortex were closely related to epilepsy after stroke,with OR being 0.374(95% CI 0.201-0.699,P=0.002).4.630(95% CI 2.041-10.501,P<0.001),0.423(95% CI 0.235-0.761,P=0.004).There was a higher risk of early-onset epilepsy with low or normal blood pressure at hospital admission(65%,P < 0.02),and a higher rate of late-onset epilepsy in the cortex of stroke(66.2%,P < 0.005).Early-onset epilepsy was dominated by partial seizures(67.5%,P < 0.001),and late seizures had a high overall seizure rate(71.6%).There was no significant difference between age and stroke with pulmonary infection in both types of epilepsy.Conclusion: The incidence of epilepsy after stroke is not significantly related to gender,previous hypertension,or diabetes,age,low or normal blood pressure at admission,cortical stroke and stroke with lung infection and post-stroke epilepsy Related,where age is a confounding factor.Low or normal blood pressure on admission,cortical apoplexy,and stroke combined with pulmonary infection were independent risk factors for post-stroke epilepsy.Low blood pressure at admission or normal risk of early-onset epilepsy is higher,and the incidence of late-onset epilepsy is higher in the cortex of the stroke.Early-onset epilepsy is dominated by partial seizures,and full seizures are more common in late-onset epilepsy.