| Objective : To investigate Guangxi Zhuang Autonomou Region of high school students of hepatitis B virus and C virus infection and popular features,indirectly evaluate the immune effect after receive hepatitis B vaccine.Analysis of the current the hepatitis B and hepatitis C prevention and treatment deficiencies and main work,and to provide scientific and targeted advices for prevention measures and control strategies of hepatitis B and hepatitis C.Methods:(1)Sampling methods: By using stratified cluster random sampling method to recruit students from high school students in Guangxi,from the 14 cities in Guangxi,according to the geographic distribution extract five representative cities from the east,south,west,north and the middle of Guangxi,which were Yulin,Nanning,Baise,Guilin and Liuzhou respectively,random select three high schools from each city,each city were randomly selected threehigh schools,which were selected were recruit all students from three classes include first-year senior high school,Senior Two and senior respectively,a total of 2700 survey,but only 2632 effective questionnaires.(2)The survey methodology: all participants were obtained the informed consent.Using specially designed epidemiological investigation questionnaire,all participants were interviewed face-to face by trained staff,For each participant,5-ml non-fasting venous blood sample was collected aseptically,and low temperature to save,to test related-indicator of hepatitis B and hepatitis C.(3)detection method: enzyme-linked immunoabsorbent assay(ELISA)detected of hepatitis B surface antigen(HBsAg),Hepatitis B Surface Antibody,Hepatitis B Core Antibody,Hepatitis B e Antigen,Hepatitis B e Antibody and hepatitis C virus antibodies(anti-HCV),the use of Rong Sheng Co.,Ltd.,Shanghai rongsheng Branch China production of ELISA reagents ere within the validity period.(4)Statistical Method: Adopted Epi Date 3.1 software to establish the questionnaire database,using SPSS16.0 software for statistical processing and analysis,Descriptive statistics were used to evaluate the popular characteristics of hepatitis B and hepatitis C of high school students,and the χ2 test method was employed to compare the differences between gender,ethnic and regional,with multi-factor logistic analysis to find related risk factors.Results:(1)Demology Features: 2632 high school students,the male to female ratio was 0.46:1,and 56.88% were Han Chinese,Zhuang and other ministry nationality were 38.72% and 4.41% respectively,age 16 years were36.36%,and 32.79% and 30.85% for age 17 years and age 18-20 years.(2)Epidemic serology features of the sign of HBV and HCV infection: 2632 students were test,among which 192 were HBs Ag positive,accounting for7.29%,1939 were HBs Ab positive,accounting for 73.67%,22 were anti-HCV positive,accounting for 0.84%,there were no statistical significance of the HBsAg positive rates,HBsAb positive rate and anti-HCV positive rates between gender and nationality(X2=3.322,0.34,0.193,X2=1.600,0.557,3.068,p>0.05).The HBsAg positive rate in the age was on statistical significant,but the difference of the HBsAb and anti-HCV positive rates in the age were statistical significant(X2= 2.025,p >0.05)),the positive of 16 years old group was the highest,but the18-20 years group was the lowest,the anti-HCV positive rate lowest at 16 years age group,the highest at 18-20 years group,differences was statistically significant in the regional distribution(X2= 85.305,6.259,p<0.05),the highest rate of positive of HBsAg in Baise region,the lowest in Guilin,but the different of anti-HCV positive in the region distribution was no statistically significant(X2=2.115,1.722,p>0.05).There were statistical significant of HBs Ag and HBsAb positive rates between Hepatitis B vaccine immunization and no receive Hepatitis B vaccine immunization(X2=71.115,32.846,p<0.05).hepatitis B vaccine immune group of HBsAg were lowest but HBsAb positive rates were highest.(3)The analysis of risk factor for HBV and HCV infection: Multi-factor logistic regression show that family history of HBV infection and person history of beauty trauma were the risk factors for hepatitisB(OR=3.616,95% CI=2.281~5.731;OR=3.057,95% CI=1.936~4.828),history of hepatitis B vaccination was the protect factory(OR=0.076,95%CI=0.051~0.111).but the history of public toothbrush and endoscopy were the risk factors for hepatitis C(OR=3.078,95% CI=1.174~48.074;OR=4.182,95%CI=1.328 ~ 13.170).(4)Composite models of HBV seromarkers: 16 kinds of Composite models of HBV seromarkers were detected in this study,the models solely positive for HBsAb was the main models accounted for 64.25%,the second composite models of HBV seromarker were positive both for HBeAb and HBcAb accounted for 17.68%,the third composite models of HBV seromarker were positive both for HBsAb and HBeAb accounted for5.59%,the composite models of HBV were positive for HBsAg,HBeAb,HBcAb and HBsAg,HBeAg,HBeAb were accounted for 2.70% and 1.33% respectively.Conclution:HBV and HCV infection were still very serious problem and every one should pay attention to this public health problem,school and relevant departments should strengthen broadcast knowledge of prevention and control strategy of hepatitis B and C,at the same time,strengthing health education to reduce the incidence of hepatitis B and hepatitis C. |
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