Comparison Factors Of Risk Between Atherosclerotic Cerebral Artery Stenosis And Lower Extremity Artery Stenosis

Background:With the continuous improvement of people's living standards in our country,bad living habits such as high fat,high salt and less exercises are common occurrences.which greatly promotes the generation and progress of atherosclerosis.However,mild atherosclerosis itself rarely has serious consequences,but one of its common endings:atherosclerosis is a serious threat to people's health and life[1].Looking at some related research results and epidemiological investigations in recent years,it is not difficult to find that there are slight differences in the site of arterial stenosis between the same part of the human arteries[2-3],showing a tendency to cause illness difference,at the same time,there are differences in the treatment of the two.The purpose of this study is to investigate the risk factors and differences in clinically common arterial stenosis of cerebral arteries and lower extremities,and to provide some references for clinicians in the prevention and treatment of related diseases.Objective:To inestigate the risk factors of the arteries of the cerebral arteries and lower extremities caused by atherosclerosis,and to find out the differences between them as far as possible.Methods:Patients who were hospitalized in Department of Neurology,Dalian Central Hospital from January 1 2014 to December 31 2017 were selected.One hundred and fifty patients were randomly selected,the patients were divided into three groups:group 1,simple cerebral artery stenosis(intracranial and external aortic artery above aortic arch),group 2,simple lower limb artery(main artery below common iliac artery branch),group 3:normal arteries group(cerebral artery and lower extremity artery were abnormal).There were 50 patients in each group.Age,Sex,History of hypertensionism,History of coronary heart disease,History of Stroke,History of smoking,History of drinking,Cholestenon(TC),triglyceride(TG),Low density lipoprotein(LDL-C),High density lipoprotein(HDL-C),Apolipoprotein A1(apo A1),Apolipoprotein B(apo B),Lipoprotein a(Lp a),Homocysteine(Hcy),Uric acid(UA),Fibrinogen(Fib)were measured in three groups of patients.A total of 18 independent variables were recorded.Using the normal arterial group as a reference,the cerebral arterial stenosis group and the lower extremity arterial stenosis group were compared with each other to screen out the statistically significant univariate variables in the 1 and 2 group,and then included in the multiple regression model.Sequential logistic regression analysis determines the ultimate risk factor type and impact.The difference was statistically significant at P<0.05.Results:1.Single factor analysis:(Statistically significant data for each comparative group is listed below)Comparison between cerebral artery stenosis group and normal vascular group:A total of 100 patients were included in this study group,and 50 patients were included in each subgroup.Cerebral artery stenosis group:TC(4.58±1.05 mmol/L),p<0.001,the difference is significant LDL-C(2.91±0.78 mmol/L),p<0.001,the difference is significant HDL-C(1.02±0.24mmol/L),p<0.001,the difference is significant Apo A1(1.27±0.19g/L),p=0.036,the difference is significant Lp A(218.74±164.48mg/d L),p=0.037,the difference is significant Hcy(15.242±8.25mmol/L),p=0.001,the difference is significant History of stroke(prevalence n=14 28%),p=0.008,the difference is significant.Above total 7 independent variables.Comparison of lower extremity arterial stenosis and normal vascular groups:A total of100 patients were included in this study group,and 50 patients were included in each subgroup.Lower extremity artery stenosis group:Sex(35 70% male,15 30% female),p=0.025,the difference is significant History of diabetes(yes n=23 46%),p=0.003,the difference is significant Age(73±9.06 years old),p<0.001,the difference is significant TC(4.43±0.93mmol/L),p<0.001,the difference is significant LDL-C(2.91±0.79mmol/L),p<0.001,the difference is significant HDL-C(0.97±0.16mmol/L),p<0.001,the difference is significant apo A1(1.27+0.19g/L),p=0.036,the difference is significant Lp a(218.74±164.48mg/d L)),p=0.037,the difference is significant Hcy(15.242±8.25mmol/L),P=0.001,the difference is significant Fib(3.68±1.27g/L),P<0.001,the difference is significant.Above total 10 independent variables.2.Multivariate analysis:Taken together the results of two single-factor comparisons,weselected gender,age,history of diabetes,history of stroke,TC,LDL-C,HDL-C,apo A1,Lp a,and Hcy on the principle of seeking common ground while reserving differences.A total of 11 explanatory variables were included in the multivariate logistic regression model.Finally,the risk factors for cerebral artery stenosis were TC and stroke.The risk factors for lower extremity arterial stenosis were TC,age,and Fib.Conclusion : High cholesterol is a common risk factor for arterial stenosis of the cerebral arteries and lower extremities,but cerebral arterial stenosis has a higher susceptibility to lower extremity arteries.At the same time,the two risk factors are also different.Previous history of stroke only had an effect on cerebral artery stenosis,while high Fib and old age were only risk factors for arterial stenosis of the lower extremities.