Effect Of Dexmedetomidine On The Postoperative Cognitive Function Of Patients Undergoing Radical Resection Of Esophageal Cancer

Objective To investigate the effect of dexmedetomidine on the postoperative cognitive function of patients undergoing radical resection of esophageal cancer.Methods A total of 76 elderlypatientsfrom January 2015 to January 2016 in the Hefei Hospital Affiliated to Anhui Medical University,including 45 males and 31 females,aged 60-85 years,of American Society Anesthesiologists physical status II or III,were selectedfor elective radical resection of esophagealcancer.All patientswere randomly and equally divided into 2 groups(n=38):observation group(group D)and control group(group C).In the control group,the patients were initially treated with 0.05 mg/kg and then with 0.02-0.08 mg/kg/h Rhythim to remain anesthetized.In the observation group,the patients were intravenously infused with 1.0 μg/kg dexmedetomidine and then with 0.2-0.7μg/kg/hto retain their anesthetized conditions.Heart rate(HR),Mean MAP and Sp O2 were recorded at entering the operating room(T0),anesthesia induction(T1),immediatelyafter intubation(T2),immediatelyafterextubation(T3),the end of operation(T4),respectively.The incidence of bradycardia,hypotension,respiratory depression and postoperativedelirium were recorded.Ramsay sedation score(RASS)was used to evaluate the time for reaching sedation effect and the recovery time after drug withdrawal.The preoperative and postoperative depression and anxiety scores of the two groups were evaluated by the self-rating Depression Scale(SDS)and self-rating Anxiety Scale(SAS),respectively.The patients in the two groups were treated with continuous intravenous pumping of fentanyl to for postoperative analgesia.The sedative effect and incidence of adverse reactions in these patients were compared.Results The sedative effects did not significantly differ between the two groups(P>0.05).The recovery time after the drug was withdrawn from the patients in the observation group was significantly shorter than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 13.16%,which was significantly lower than that in the control group(39.47%;P<0.05).The postoperative SDS and SAS scores of the patients in the two groups were significantly higher than their preoperative scores(P<0.05).The postoperative SDS and SAS scores of the patients in the observation group were also significantly higher than those in the control group(P<0.05).Conclusion The sedative effect of dexmedetomidine on patients subjected to general anesthesia and undergoing radical resection of esophageal cancer was good.It could reduce the incidence of adverse reactions.Therefore,this drug has certain advantages in such patients.