| Background and Objective: Type 2 diabetesmellitus is a common chronic disease with high glucose.,with the development of society,changes in people's lifestyles and environmental pollution,the incidence of diabetes increased year by year,the number of diabetic patients increased rapidly.Diabetes complications have brought great harm to patients,it is very important to reduce the risk of diabetic complications to patients.Dysfunction ofislet ?-cell function play an important role in the development of diabetes,with the increase of blood glucose,the function of islet ?-cell function gradually declines until failure,and the patient's blood glucose control will be worse and worse,which will bring greater harm to patients.Factors such as obesity,sugar toxicity,lipotoxicity,deposition of amylin,inflammatory reaction and oxidative stress all induce the apoptosis of islet ?-cells and affect the function of islet ?-cells.Glycosylated hemoglobin(Hb A1c)was used as a "gold standard" for assessing glycemic control,with the development of continuous blood glucose monitoring system(CGMS),more and more studies have shown that the fluctuation of blood glucose is closely related to the chronic complications of diabetes.The harm of glucose fluctuation is greater thanpersistent hyperglycemia,glucose fluctuations is an important indicator to assess the patient's glycemic control.To analyze the relationship between islet ?-cell function and glucose fluctuation in patients with type 2 diabetes mellitus,to investigate the effect of glucose fluctuation and hyperglycemia on pancreatic ?-cell function in type 2 diabetes mellitus,warned people should focus on reducing the risk of glucose fluctuation to type 2 diabetes mellitus.Methods: 99 patients with T2 DM from January 2016 to March 2017 in our department of Endocrinology were selected to analyze,including 73 males,26 females,which were line with the 1999 who diagnostic criteria for diabetes,we collected the patient,s clinical,including age,sex,duration of diabetes mellitus,height,weight.All patients received oral glucose tolerance test(OGTT)or 100 g standard steamed bread meal test,and calculate the standard deviation of blood glucose(SDBG)according to the results of fingertip blood glucose monitoring,which indicates the patient's glucose fluctuation.Use CPR index(serum C-peptide immunoreactivity index),SUIT(secretory units of islets in transplantation),FCP(fasting C-peptide),CP2h(C-peptide 2 hour)indicates the patient's islet ?-cell function.Analyzed the relationship of CPR index,SUIT,FCP,CP 2 h and SDBG.Patients were divided into Hb A1c?7.5%,7.5%<Hb A1c?10% and Hb A1c>10% 3 groups according to their Hb A1 c level,to analyse the difference of islet ?-cell function between the three groups.Results:1.The relationship of CPR index?SUIT0?SUIT120?FCP,CP 2 h and SDBG was negative correlation(r were-0.314,-0.274,-0.483,-0.245,-0.346;P were 0.002,0.006,0.000,0.014,0.000).(SUIT0 and FCP is the index of fasting,SUIT120 and CP2h is the index of 2 hours after the OGTT or 100 g standard steamed bread meal test)2.Except SUIT0 had no significant difference between 7.5%<Hb A1c?10% group with Hb A1c>10% group,FCP had no significant difference between Hb A1c?7.5% group with 7.5%<Hb A1c?10% group,other indexes were statistically significant differencebetween 3 groups(P < 0.05).Conclusion: The pancreatic ?-cell function and glucose fluctuation in patients with T2 DM have a significant correlation,pancreatic ?-cell function are differences with three group,we should focus on reducing the risk of glucose fluctuation to type 2 diabetes mellitus. |
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