Effect Of Ultrasonic Kidney Depth Correction On Glomerular Filtration Rate Measured By Renal Dynamic Imaging In Patients With Hydronephrosis

Objective:To compare the glomerular filtration rate?GFRs?measured by Gates method based on ^99mTc-DTPA renal dynamic imaging before and after ultrasonic depth correction in patients with different degrees of hydronephrosis.Methods:Renal dynamic images of 113 patients?65 males,48 females;average age:?45.7±10.3?years?with hydronephrosis from October 2015 to October 2016 were retrospectively analyzed.The GFRs were also determined with cystatinC?Cys C?method within 1 week.According to the degree of hydronephrosis,patients were divided into mild,moderate,severe hydronephrosis groups.The GFRs?total GFR,GFR of the ill kidney,GFR of the normal kidney?were determined by Gates method,and were measured again after the kidney depth being corrected by ultrasound.One-way analysis of variance analysis,the least significant difference t test and paired t test were used.Results:In severe hydronephrosis group?n=55?,GFRs?ml·min-1·1.73 m-2?of the ill kidney before and after the depth correction were significant different?14.9±6.2 vs 9.6±5.8;t=4.63,P<0.05?,and total GFR?ml·min-1·1.73 m-2?before depth correction and GFR?ml·min-1·1.73 m-2?determined by Cys C method was also significantly different?32.1±12.2 vs 26.2±10.2;F=1.58,t=2.75,P<0.05?.There was no significant difference between GFRs before and after depth correction,between total GFR and GFR measured by CysC method in mild?n=43?and moderate hydronephrosis groups?n=15?,and between total GFR after being corrected and GFR measured by CysC method in severe group?F values:1.72².39,t values:0.31-0.91,all P>0.05?.Conclusions:Ultrasonic depth correction may have greater clinical significance in GFR measurement by renal dynamic imaging for patients with severe hydronephrosis.