| Background:Hearth failure is a serious and terminal stage of cardiovascular disease,which is one of the cardiovascular diseases that seriously affect public health,the five-year survival rate is similar to malignant tumors.According to the updated ESC guidelines for the diagnosis and treatment of acute and chronic heart failure,heart failure can be classified into heart failure with preserved ejection fraction,heart failure with mid-range ejection fraction and heart failure with reduced ejection fraction.The morbidity of heart failure with preserved ejection fraction has been increased in recent years.It has become the most common type of heart failure,and it's all-cause mortality is similar to that of heart failure with reduced ejection fraction.Diabetes is the most common comorbidity of heart failure with preserved ejection fraction,which is about 38% patients with heart failure and preserved ejection fraction coexist with diabetes.Previous studies has shown that diabetes increases cardiovascular mortality in heart failure with reduced ejection fraction.However,few studies have been made in patients with heart failure and preserved he ejection fraction.Although the mechanism is not clear in currently,diabetes may play an important role in the pathophysiology of heart failure with preserved ejection fraction.In this study,the clinical characteristics and echocardiographic characteristics of heart failure with heart failure and preserved ejection fraction were compared and analyzed.Methods:476 patients with heart failure and preserved ejection fraction who have been hospitalized in the First Affiliated Hospital of Dalian Medical University from January 2016 to October 2017 are enrolled in our study.The patients were demanded to provide their disease history and basic personal information,then accept a series of medical examinations,including dynamic electrocardiography,ultrasonic cardiogram and laboratory test.According to the history of diabetes,the patients were divided into diabetes and no diabetes groups.Statistical analysis(SPSS22.0)was used to analyze the differences between the two groups,the normal distribution data were compared by independent sample t test.The data of non-normal distribution were compared by Mann Whitney U test.The count data were compared between the chi square test or the exact Fisher test.Results:1.Comparison of baseline data and clinical characteristics between diabetes and no diabetes groups: There are differences between groups in NYHA class,weight,systolic blood pressure,history of hypertension,history of coronary heart disease,?-blockers utilization,calcium channel blockers utilization,satins utilization and anti-platelets utilization.Compared to those without diabetes,they were more likely to have a history of hypertension and coronary heart disease,higher NYHA class,higher weight,higher systolic blood pressure,higher utilization of ?-blockers,calcium channel,anti-platelets and satins.2.Comparison of dynamic electrocardiography data between diabetes and no diabetes groups: There are no differences between two groups in average heart rate,R-R interval more than two seconds,atrial premature beats,atrial tachycardia,ventricular premature beats and ventricular tachycardia.3.Comparison of laboratory test result between diabetes and no diabetes groups: There are differences between groups in white blood cell count,neutrophil count,glucose,urea nitrogen,serum creatinine,triglyceride,serum potassium,hemoglobin,high density lipoprotein cholesterol.Compared to those without diabetes,they were more likely to have a higher white blood cell count,higher neutrophil count,higher glucose,higher urea nitrogen,higher serum creatinine,higher triglyceride,higher serum potassium,lower hemoglobin,lower high density lipoprotein cholesterol.There are no differences between two groups in other laboratory test.4.Comparison of electrocardiography data between diabetes and no diabetes groups: There are differences between groups in septum wall thickness,left ventricular posterior wall thickness,Doppler E wave velocity and ratio of E/e'.Patents with diabetes had a greater Septum wall thickness(11.45 cm vs.11.01cm)and left ventricular posterior wall thickness(10.56 cm vs.10.14cm).Doppler E wave velocity(102.80cm/s vs 95.98cm/s)and ratio of E/e'(13.77 vs.11.85)were higher in patients with diabetes.Conclusions:1.Patients with diabetes had a more worse cardiac function,and a more history of hypertension and coronary heart disease.2.The diastolic function is more worse in patients with diabetes than no diabetes by electrocardiography. |
PDF Full Text Request