Influence Of Cow’s Milk Protein Allergy On The Diagnosis Of Functional Gastrointestinal Diseases Based On The Rome Ⅳ Standard In Infants And Young Children

Objective:This study investigated the etiology of CMPA and explored the effect of CMPA on the diagnosis of FGID based on the Rome IV standard in infants and young children.Methods:A total of 84 children aged 1 month to 3 years who were diagnosed with CMPA were enrolled as the case group,and 84 infants and young children had no CMPA were enrolled as the control group.The pediatricians specializing in gastroenterology asked parents using a questionnaire for the diagnosis of FGID based on the Rome IV standard to assess clinical symptoms and to diagnose FGID.Results:There were 84 cases in the case group,including 45 males and 39 females.The control group was 84 cases infants,including 48 males and 36 females.There was no statistically significant difference in the average age between the two(p>0.05).The digestive tract symptom was found in 49 cases(58%)in the case group,while in the control group there were 16 cases(19%)of digestive tract symptoms,the difference was statistically significant(p<0.05).The main factors of milk protein allergy include:Infants often use skin care products.The first food eaten in three days is milk.Milk is mainly food in infants for 4 months.Large amount of eggs,shrimp,crabs and milk for mother when pregnant or breastfeeding.Large amount of nuts,peanuts and mangoes for mother when pregnant or breastfeeding.Parents engages in chemical industry,construction,manufacturing.Living around a chemical plant,toy factory,shoe factory.House was recently renovated.Family members have a history of allergies.The case group had a significantly higher incidence rate of a family history of allergies than the control group(P<0.05).In the case group,38(45%)met the Rome IV standard for the diagnosis of FGID,while in the control group,13(15%)met this standard(P<0.05).According to the Rome IV standard for FGID,the case group had significantly higher diagnostic rates of reflex,functional diarrhea,difficult defecation,and functional constipation than the control group(P<0.05)The children who were diagnosed with FIGD in the control group were given conventional treatment,and those in the case group were asked to avoid the intake of cow’s milk protein in addition to the conventional treatment.After 3 months of treatment,the case group had a significantly higher response rate to the treatment than the control group(P<0.05).Conclusion:In infants and young children,CMPA has great influence on the diagnosis of FGID based on the Rome IV standard.The possibility of CMPA should be considered during the diagnosis of FGID.