| After three years clinical training in orthopedic traumatology at Southern Medical University and the standardized training of practicing physicians,I got a profound understanding of orthopedic knowledge,especially in osteomyelitis.Therefore,Osteomyelitis-related issues was chosen as the research direction.Osteomyelitis is an orthopedic disease that can be caused by trama,fracture,or blood-borne infection,and is mainly characterized by bone loss and bone destruction.In its clinical manifestations,the basis of pathophysiology and related diagnosis and treatment are a heterogeneous disease.The cause of the disease is mostly due to adjacent soft tissue and joint dissemination,blood spread or trauma and surgery caused by pathogenic bacteria directly attached to the bone.In recent years,with the theory of injury control and the continuous improvement of trauma treatment technology,the incidence of traumatic osteomyelitis has also risen steadily while improving the post-traumatic survival rate.The incidence of traumatic osteomyelitis is affected by the degree of soft tissue injury,the type of fracture,the choice of treatment mode,the placement of the implants and the biomechanical structure.In recent years,with the rapid economic development in our country,the process of China's industrialization of machinery and the popularization of vehicles such as cars,so that the incidence of various types of trauma has also increased year by year,followed by the incidence of traumatic osteomyelitis is also increasing year by year.In the United States,the incidence of osteomyelitis has risen from 11.4 cases per 100,000 person-years in 1969-1979 to 24.4 cases per 100,000 person-years in 2000-2009 and still present an upward trend.However,there is currently no accurate epidemiological data on the incidence of osteomyelitis in China.However,we hypothesize that for a developing country with a large population base and heavy road traffic pressure,the incidence of osteomyelitis in Chinese people,especially traumatic bone marrow The incidence of inflammation may be higher.In the treatment of osteomyelitis,with the development of masqulet intramedullary osteosynthesis and ilizarov osteotomies combined with the development of microvascular surgical techniques for the treatment and repair of soft tissues and the emergence of novel antibiotic carriers,The progress of internal fixation materials and technology and the improvement of multidisciplinary trauma management strategies have made tremendous progress in the treatment of osteomyelitis.Nevertheless,the diagnosis and treatment of osteomyelitis is still a huge challenge for clinicians.Infectious osteomyelitis caused by many factors has the characteristics of easy recurrence of infection,long costly treatment period,Bring great inconvenience to patients' life and work and even cause mental illness,and bring great economic burden to families and society.Therefore,in order to be able to better solve these problems,we need to conduct an in-depth and systematic study of the disease.The purpose of this project is to investigate the mechanism of how osteomyelitis caused by bacterial infection leads to bone loss.Based on the understanding of osteomyelitis,this paper mainly includes the following two parts,the first part:Study on the reduction of bone mass caused by Staphylococcus aureus ?-hemolysin.The effect of a-hemolysin on bone mass was explored at the animal and cell levels by microCT,RT-PCR and other related techniques.Part ?:In this section we review the research progress of microRNA and osteomyelitis pathogenesis,summarizes the microRNA-24,microRNA-29,microRNA-223 And other signaling transduction on osteogenic differentiation may exist mechanisms. |
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