Research Of Menopausal Hormone Therapy After Cervical Squamous Cell Carcinoma Treatment

Objective:To study the efficacy and safety of Menopausal Hormone Therapy(MHT)in cervical squamous cell carcinoma patients with menopausal symptoms after treatments.Methods:150 cases of cervical squamous cell carcinoma patients in stage Ⅰa2-Ⅱb were recruited and grouped according to treatment methods(surgery or radiotherapy,retaining ovaries or not during surgery)and whether menopausal symptoms were treated with menopausal hormone therapy.Each group was detected in serum follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)levels by radioimmunoassay(RIA),serum SCC-Ag,Kupperman Scores for menopause symptoms and EORTC.QLQ-C30 for the quality of life after 3 months,6 months and 1 year treatment.Serum hormone levels,menopausal symptoms,quality of life and serum SCC-Ag were compared across groups to study efficacy and safety of MHT in cervical squamous cell carcinoma patients with menopausal symptoms after treatment.Results:1.Compared with before and after using MHT in ovariectomized and using MHT groups,after using MHT,the Kupperman score decreased,menopause symptoms improved,serum FSH and LH levels decreased,serum E2 increased and overall quality of life was better than before using MHT.The differences had statistically significant(P<0.05).2.The ovarian preservation group was compared with the ovariectomy and using MHT group.The Kupperman score,serum FSH and LH levels of ovarian preservation group were lower than the ovariectomy and using MHT group.Menopause symptoms of ovarian preservation group were lighter than the ovariectomy and using MHT group.The serum E2 levels of ovarian preservation group was higher than the ovariectomy and using MHT group.The overall quality of life was better than the ovariectomy and using MHT group.The differences had statistically significant(P<0.05).The serum SCC-Ag values of the two groups were compared and the difference had not statistically significant(P>0.05).3.The ovariectomy and using MHT group was compared with the ovariectomy group.The Kupperman score,serum FSH and LH levels of ovariectomy and using MHT group were lower than the ovariectomy group.Menopause symptoms of ovariectomy and using MHT group were lighter than the ovariectomy group.The serum E2 levels of ovariectomy and using MHT group was higher than the ovariectomy group.The overall quality of life was better than the ovariectomy group.The differences had statistically significant(P<0.05).The serum SCC-Ag values of the two groups were compared and the difference had not statistically significant(P>0.05).4.Compared with radiotherapy and using MHT group before and after using MHT,after using MHT,the Kupperman score decreased,menopause symptoms improved,serum FSH and LH levels decreased,serum E2 increased and overall quality of life was better than before using MHT.The differences had statistically significant(P<0.05).5.The radiotherapy and using MHT group was compared with the radiotherapy control group.The Kupperman score,serum FSH and LH levels of radiotherapy and using MHT group were lower than the radiotherapy control group-Menopause symptoms of radiotherapy and using MHT group were lighter than the radiotherapy control group.The serum E2 levels of radiotherapy and using MHT group was higher than the radiotherapy control group.The overall quality of life was better than the radiotherapy control group.The differences had statistically significant(P<0.05).The serum SCC-Ag values of the two groups were compared and the difference had not statistically significant(P>0.05).Conclusions:1.Cervical squamous cell carcinoma patients after surgery or radiotherapy can use estrogen alone to effectively reduce serum FSH,LH levels,increase serum E2 levels,improve menopausal symptoms caused by low estrogen and significantly improve the quality of life of patients.2.Young cervical squamous cell carcinoma patients undergoing intraoperative ovarian suspension can maintain normal ovarian endocrine function and avoid the symptoms of menopause to improve the quality of life.3.Cervical squamous cell carcinoma patients treated with estrogen only has no effect on tumor recurrence and metastasis in the short term.