Analysis Of Prognostic Factors In 575 Cases Of Renal Carcinoma

OBJECTIVE: The complete prognostic factors of renal cell carcinoma(RCC)of Xinjiang Medical University Affiliated Tumor Hospital were verified and the applicability of the relevant prognostic evaluation system was judged.METHODS: The data of 575 pathologically diagnosed RCCs were consulted,and indicators related to the prognosis of RCC were collected.MSKCC risk scores and HENG scores were used to grade metastatic renal cell carcinoma(m RCC)samples,UISS scores and SSIGN scores were used to grade the risk of clear cell renal cell carcinoma(ccRCC)samples.Using the Kaplan-Meier single factor method and life table for mRCC samples,non-metastatic renal cell carcinoma(nmRCC)samples,and ccRCC samples.The survival rate of the patients was analyzed by using log rank to examine the differences in the survival rates of each index,and the factors that affected the survival of the patients were analyzed.The multivariate analysis of the COX regression model was used to identify the prognostic factors associated with this study.The rank sum test was used to evaluate a scoring system that is more suitable for the prognosis of renal cancer in this area.RESULTS:(1)Multivariate analysis of COX regression model for MSKCC risk score and HENG score showed that systemic treatment,KPS score and HB were independent prognostic factors of mRCC patients(P<0.05).(2)UISS score and SSIGN score were verified.The results showed that the age of onset,serum albumin,and ECOG-PS score were independent prognostic factors of cc RCC patients(P<0.05).(3)COX multivariate analysis showed that diabetes,type of operation,HB,and lymph node involvement were independent prognostic factors in patients with nmRCC(P<0.05).(4)The Kruskal-Wallis H method verifies that the P value of UISS score is more accurate than the SSIGN score,and the P value of the MSKCC risk score is more accurate than the Hung score.CONCLUSION: Lymph node involvement is a prognostic risk factor for patients with nmRCC.Normal,non-diabetic HB and surgical treatment are prognostic factors for patients with nmRCC.Systemic treatment,a KPS score of >80,and normal HB are prognostic factors for death in mRCC patients.Age <60 years,serum albumin ≥35 g/L is a prognostic factor for patients with cc RCC,and ECOG-PS score ≥1 is a prognostic risk factor for patients with ccRCC.The MSKCC risk score is more suitable for the prognosis of mRCC patients in the region than the HENG score.The UISS score is more suitable for the prognosis of ccRCC patients in this region than the SSIGN score.